Mendelian randomisation, lipids, and cardiovascular disease : The Lancet

Mendelian randomisation, lipids, and cardiovascular disease : The Lancet

The Lancet, Early Online Publication, 17 May 2012

doi:10.1016/S0140-6736(12)60481-4Cite or Link Using DOI

Mendelian randomisation, lipids, and cardiovascular disease

Seamus C Harrison a, Michael V Holmes b, Steve E Humphries a

In The Lancet, Benjamin Voight and colleagues 1 use mendelian randomisation analysis to investigate the relation between HDL cholesterol and coronary heart disease. High HDL cholesterol concentration is associated with reduced risk of coronary heart disease in observational studies, 2 but whether the association is causal cannot be unequivocally ascertained from these studies alone, and whether raising of HDL cholesterol would be an effective means to reduce risk of coronary heart disease remains unce ...