Am J Epidemiol. 2009 Sep 15;170(6):703-7. Epub 2009 Aug 11.
Invited commentary: genes, environment, and hybrid vigor.
SourceOffice of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia 30341 , USA. email@example.com
AbstractIn the 1950s, case-control studies of smoking and lung cancer established a paradigm for epidemiologic studies of risk factors for chronic diseases. Since then, thousands of case-control studies have examined possible associations of countless risk factors with numerous diseases, rarely finding associations as strong or consistent as that of smoking with lung cancer. Recently, researchers have applied advances in molecular genetics to conduct candidate gene and genome-wide association studies of lung cancer. Skeptics among both epidemiologists and geneticists have argued that genomic research adds little value when most cases of disease can be attributed to a preventable exposure; however, well-conducted studies of gene-environment interactions that draw on data from more than 50 years of research in toxicology, pathophysiology, and behavioral science offer important models for the development of more comprehensive approaches to understanding the etiology of chronic diseases.
Invited Commentary: Genes, Environment, and Hybrid Vigor
- [PubMed - indexed for MEDLINE]