Dose Response Between Physical Activity and Risk of Coronary Heart Disease

open here please ►Dose Response Between Physical Activity and Risk of Coronary Heart Disease: "* Original Article

Dose Response Between Physical Activity and Risk of Coronary Heart Disease
A Meta-Analysis

1. Jacob Sattelmair, MSc, ScD;
2. Jeremy Pertman, MS;
3. Eric L. Ding, ScD;
4. Harold W. Kohl III, PhD;
5. William Haskell, PhD;
6. I-Min Lee, MBBS, ScD

+ Author Affiliations

1. From the Department of Epidemiology, Harvard School of Public Health, Boston, MA (J.S., J.P.); Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Department of Nutrition, Harvard School of Public Health, Boston, MA (E.L.D.); Division of Epidemiology, Genetics and Environmental Health Sciences, University of Texas Health Science Center–Houston, Department of Kinesiology and Health Education, University of Texas at Austin (H.W.K.); Stanford Center for Research in Disease Prevention, Stanford Medical School, Stanford, CA (W.H.); Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Department of Epidemiology, Harvard School of Public Health, (I.-M.L.).

1. Correspondence to Jacob Sattelmair, 6 Marlborough St, 5d, Boston, MA, 02116. E-mail sattelmair@post.harvard.edu

Abstract

Background—No reviews have quantified the specific amounts of physical activity required for lower risks of coronary heart disease when assessing the dose-response relation. Instead, previous reviews have used qualitative estimates such as low, moderate, and high physical activity.

Methods and Results—We performed an aggregate data meta-analysis of epidemiological studies investigating physical activity and primary prevention of CHD. We included prospective cohort studies published in English since 1995. After reviewing 3194 abstracts, we included 33 studies. We used random-effects generalized least squares spline models for trend estimation to derive pooled dose-response estimates. Among the 33 studies, 9 allowed quantitative estimates of leisure-time physical activity. Individuals who engaged in the equivalent of 150 min/wk of moderate-intensity leisure-time physical activity (minimum amount, 2008 US federal guidelines) had a 14% lower coronary heart disease risk (relative risk, 0.86; 95% confidence interval, 0.77 to 0.96) compared with those reporting no leisure-time physical activity. Those engaging in the equivalent of 300 min/wk of moderate-intensity leisure-time physical activity (2008 US federal guidelines for additional benefits) had a 20% (relative risk, 0.80; 95% confidence interval, 0.74 to 0.88) lower risk. At higher levels of physical activity, relative risks were modestly lower. People who were physically active at levels lower than the minimum recommended amount also had significantly lower risk of coronary heart disease. There was a significant interaction by sex (P=0.03); the association was stronger among women than men.

Conclusions—These findings provide quantitative data supporting US physical activity guidelines that stipulate that “some physical activity is better than none” and “additional benefits occur with more physical activity.”
Key Words:

* coronary heart disease
* exercise
* meta-analysis
* physical activity
* women

* Received November 28, 2010.
* Accepted June 2, 2011.

* © 2011 American Heart Association, Inc.

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Actualidad Ultimas noticias - JANOes - Cuantifican los beneficios del ejercicio para el corazon - JANO.es - ELSEVIER: "CARDIOLOGÍA
Cuantifican los beneficios del ejercicio para el corazón

JANO.es · 02 Agosto 2011 11:01


Un estudio que incluso las personas que realizan una actividad física por debajo de las directrices estadounidenses (2 horas y 30 minutos de ejercicio moderado a la semana), contraen un menor riesgo de dolencias cardíacas.

Las personas que realizan alguna actividad física de intensidad moderada durante 150 minutos a la semana tienen un 14% menos de posibilidades de sufrir una enfermedad cardiaca coronaria que aquellos que no realizan ningún ejercicio físico.

Un estudio publicado en la revista Circulation, de la Asociación Americana del Corazón, revela que incluso las personas que realizan una actividad física por debajo de las directrices estadounidenses (2 horas y 30 minutos de ejercicio moderado a la semana), contraen un menor riesgo de dolencias cardíacas.

'Las conclusiones generales del estudio corroboran las pautas federales, que señalan que 150 minutos de ejercicio a la semana es beneficioso, 300 minutos por semana es aún mejor', afirma el doctor Jacob Sattelmair, del Departamento de Epidemiología del Harvard School of Public Health.

Sattelmair explica que, a diferencia de trabajos anteriores, éste incluye la evaluación cuantitativa de la cantidad de actividad física que una persona necesita para reducir el riesgo, así como la magnitud del beneficio. Los investigadores examinaron más de 3.000 estudios sobre actividad física y enfermedades del corazón, e incluyeron 33 de ellos en su análisis.

'Los primeros estudios dividían a las personas en activos o sedentarios. Los estudios más recientes han comenzado a evaluar la cantidad real de actividad física que un individuo realiza y cómo se relaciona este hecho con el riesgo de padecer enfermedades del corazón', dice Sattelmair.


Circulation (2011); doi: 10.1161/​CIRCULATIONAHA.110.010710
Dose Response Between Physical Activity and Risk of Coronary Heart Disease: "- Enviado mediante la barra Google"

Circulation
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