Comparison of four prognostic scores in peripheral T-cell lymphoma — Ann Oncol

Ann Oncol (2011) 22 (2): 397-404.
doi: 10.1093/annonc/mdq359
First published online: July 14, 2010

Comparison of four prognostic scores in peripheral T-cell lymphoma
G. Gutiérrez-García1, A. García-Herrera2, T. Cardesa2, A. Martínez2, N. Villamor2, G. Ghita1, A. Martínez-Trillos1, L. Colomo2, X. Setoain3, S. Rodríguez4, E. Giné1, E. Campo2 and A. López-Guillermo1,*



+ Author Affiliations
1Department of Hematology
2Department of Pathology
3Department of Nuclear Medicine
4Department of Radiology, Hospital Clínic, Institut de Recerca Biomèdica August Pi i Sunyer, Barcelona, Spain


*Correspondence to: Dr A. López-Guillermo, Department of Hematology, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain. Tel: +34-932275475; Fax: +34-932275484; E-mail: alopezg@clinic.ub.es


Received April 7, 2010.
Revision received May 14, 2010.
Accepted May 19, 2010.


Abstract
Background: To compare the usefulness of four prognostic scores in patients with peripheral T-cell lymphoma (PTCL) from a single institution.

Patients and methods: One hundred twenty-one patients (77 male/36 female, median age 53 years) with PTCL [anaplastic large-cell lymphoma (ALCL) 21, PTCL not otherwise specified 56 and other 44)]. Complete response (CR) rate and 5-year overall survival (OS) were 41% and 31%, respectively. International Prognostic Index (IPI), Prognostic Index for T-cell lymphoma (PIT), International peripheral T-cell lymphoma Project score (IPTCLP) and modified Prognostic Index for T-cell lymphoma (mPIT) were calculated as in the original references. mPIT was only assembled to 41 patients in whom Ki-67 immunostaining was available. ALCL patients were analyzed separately.

Results: Concordance among IPI, PIT and IPTCLP was 52% for low-risk group, 27% for low/intermediate-risk group, 20% for high/intermediate-risk group and 14% for high-risk group. IPI, PIT and IPTCLP predicted CR, with IPI being the best score in logistic regression. Neither Ki-67 immunostaining nor mPIT predicted CR. Five-year OS (low-risk versus intermediate- or high-risk categories) according to IPI, PIT, IPTCLP and mPIT were 52% versus 45%, 75% versus 49%, 58% versus 20% and 39% versus 0%, respectively. IPTCLP was the best score for OS in multivariate analysis.

Conclusion: All the scores demonstrated their usefulness to assess the outcome of patients with PTCL, with IPTCLP being the most significant to predict OS.


Comparison of four prognostic scores in peripheral T-cell lymphoma — Ann Oncol