On January 10, 2011, the Department of Health and Human Services Panel on Antiretroviral Guidelines for Adults and Adolescents released updated Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents.
The updated guidelines can be viewed and downloaded from the Adult and Adolescent Guidelines section of the AIDSinfo web site at http://aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf.
Key changes, summarized in the preface to the guidelines, entitled What's New in the Guidelines?, are highlighted in yellow throughout the guidelines document. The changes affect the following sections:
Introduction
CD4 T-cell Count
Viral Load Testing
Drug-Resistance Testing
What to Start: Initial Combination Regimens for the Antiretroviral-Naïve Patient
Hepatitis B (HBV)/HIV Coinfection
Mycobacterium Tuberculosis Disease with HIV Coinfection
Adverse Effects of Antiretroviral Agents
The following sections and their relevant tables have also been updated:
• Coreceptor Tropism Assays
• Treatment Goals
• Initiating Antiretroviral Therapy in Treatment-Naïve Patients
• What Not to Use
• Virologic and Immunologic Failure (previously titled “Management of Patients with Antiretroviral Treatment Failure”)
• Regimen Simplification
• Exposure-Response Relationship and Therapeutic Drug Monitoring for Antiretroviral Agents
• Acute HIV Infection
• HIV and Illicit Drug Users (with new Table)
• HIV-2 Infection
• Drug Interactions (and Tables)
• Drug Characteristics Tables (Appendices)
Richard Klein
Office of Special Health Issues
Food and Drug Administration
Kimberly Struble
Division of Antiviral Drug Products
Food and Drug Administration
AIDSinfo - HIV / AIDS Information
AIDSinfo - HIV / AIDS Information
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