Too little or too much testosterone may matter for heart rhythm

Conflicting clinical trials and emerging mechanistic evidence are reshaping how researchers think about testosterone levels, replacement therapy, and the heart’s electrical rhythm. https://www.news-medical.net/news/20260902/Too-little-or-too-much-testosterone-may-matter-for-heart-rhythm.aspx In a recent review published in the Journal of the Endocrine Society, researchers investigated the effects of serum testosterone levels and testosterone replacement therapy (TRT) on the risk of atrial fibrillation (AF). The evidence was not consistent across studies, but several reports pointed to a higher AF risk at both low and high testosterone levels. This may be relevant when assessing AF risk in men receiving or considering TRT, although the association still needs to be confirmed in future studies.