Beyond Base Pairs to Bedside: A Population Perspective on How Genomics Can Improve Health.

Khoury MJ, Gwinn M, Bowen MS, Dotson WD.

Source

1 Centers for Disease Control and Prevention.

Abstract

A decade after the sequencing of the human genome, the National Human Genome Research Institute announced a strategic plan for genomic medicine. It calls for evaluating the structure and biology of genomes, understanding the biology of disease, advancing the science of medicine, and improving the effectiveness of health care. Fulfilling the promise of genomics urgently requires a population perspective to complement the bench-to-bedside model of translation. A population approach should assess the contribution of genomics to health in the context of social and environmental determinants of disease; evaluate genomic applications that may improve health care; design strategies for integrating genomics into practice; address ethical, legal, and social issues; and measure the population health impact of new technologies. (Am J Public Health. Published online ahead of print November 17, 2011: e5-e8. doi:10.2105/AJPH.2011.300299).