Uncovering how obesity leads to Alzheimer’s disease It’s long been recognized that obesity in midlife significantly raises the risk of Alzheimer’s disease. A new study shows the biological mechanisms that contribute to pathogenesis. Written byAllison Whitten, PhD

https://www.drugdiscoverynews.com/uncovering-how-obesity-leads-to-alzheimer-s-disease-17179 The biggest risk factor in the development of Alzheimer’s disease (AD) is one that can’t be controlled: the act of aging itself. But there are other risk factors that lay the groundwork for the disease earlier in life that can be changed — like obesity during midlife. The presence of obesity in middle age can mean up to a 74 percent increased risk of developing dementia, clearly signaling a key relationship between excess adipose tissue and neurodegeneration in the brain. Yet, the biological mechanisms linking the two have remained a mystery.