jueves, 31 de julio de 2025
Perceived sickness activates real immune responses
https://www.news-medical.net/news/20250731/Perceived-sickness-activates-real-immune-responses.aspx
In a new experiment, scientists used virtual reality to show that the brain can sense virtual infection to trigger the body’s immune system, before the first microbe ever makes contact.
An overview of FeNO guidelines in clinical practice
https://www.news-medical.net/whitepaper/20250728/An-overview-of-FeNO-guidelines-in-clinical-practice.aspx
Fractional exhaled Nitric Oxide (FeNO) is widely used in both primary and secondary care settings across the world. Many regions recommend incorporating FeNO-guided management into their clinical standards, and resulting FeNO-related guidelines can vary across the UK and other countries. The following explores and compares these approaches.
Myeloma Expert: Is Early Immunotherapy a Game Changer? Mary Ellen Schneider July 31, 2025 ++++
https://www.medscape.com/viewarticle/myeloma-expert-early-immunotherapy-game-changer-2025a1000kcz
Me-Too Cancer Drugs Not Often Compared to Original
Edited by Gargi Mukherjee
https://www.medscape.com/viewarticle/me-too-cancer-drugs-not-often-compared-original-2025a1000kat
July 31, 2025
Dupilumab Helps Sustain Cancer Treatment by Controlling ADC Skin Toxicities
Edited by Deepa Varma
https://www.medscape.com/viewarticle/dupilumab-helps-sustain-cancer-treatment-controlling-adc-2025a1000kal
July 30, 2025
Novel Combo Boosts Survival in IDH1-Mutated AML
Edited by Susan Ruel, PhD
https://www.medscape.com/viewarticle/novel-combo-boosts-survival-idh1-mutated-aml-2025a1000kam
July 30, 2025
Absolute and relative risks of mental disorders in families: a Danish register-based study + +... +
https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(25)00196-8/abstract?utm_campaign=update-lanpsy&utm_medium=email&dgcid=hubspot_update_feature_updatealerts_lanpsy&_hsenc=p2ANqtz-8tognIlQrPC6Be1TcBmBvkeP2pAETLaoOynZcUTQa_dvYnE4eGP_jwF_nugSWGTggIS99xBcryEVVKf1-s-RIXCQ96KQ&_hsmi=373683497&utm_content=372960347&utm_source=hs_email
Editorial
p543
Mental health in all policies
The Lancet Psychiatry
https://www.thelancet.com/journals/lanpsy/issue/vol12no8/PIIS2215-0366(25)X0008-0
Real-world effectiveness of clozapine augmentation with antidepressants: within-subject data evidence from two European nationwide cohorts
https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(25)00163-4/abstract?utm_campaign=update-lanpsy&utm_medium=email&dgcid=hubspot_update_feature_updatealerts_lanpsy&_hsenc=p2ANqtz--jKETkNPz5vRR-eXGu3XqUNo3GiAbqHs3i0cBEGhM5Qoa-p6jdUOY0-diZCrerm6Ios4nGdyZbYBwGE3TCGWImXW_Lyg&_hsmi=373683497&utm_content=372960347&utm_source=hs_email
Editorial Daring to dream of long-acting HIV prevention + + +...
https://www.thelancet.com/journals/lanhiv/article/PIIS2352-3018(25)00194-8/fulltext?dgcid=raven_jbs_etoc_email
Aug 2025
Volume 12Number 8e537-e602
https://www.thelancet.com/journals/lanhiv/issue/vol12no8/PIIS2352-3018(25)X0008-4
Safety and immunogenicity of investigational tuberculosis vaccine M72/AS01E–4 in people living with HIV in South Africa: an observer-blinded, randomised, controlled, phase 2 trial
https://www.thelancet.com/journals/lanhiv/article/PIIS2352-3018(25)00124-9/fulltext?dgcid=raven_jbs_etoc_feature_lanhiv
miércoles, 30 de julio de 2025
Effects of retatrutide on body composition in people with type 2 diabetes: a substudy of a phase 2, double-blind, parallel-group, placebo-controlled, randomised trial +...
https://www.thelancet.com/journals/landia/article/PIIS2213-8587(25)00092-0/abstract?utm_campaign=update-landia&utm_medium=email&dgcid=hubspot_update_feature_updatealerts_landia&_hsenc=p2ANqtz--ZCWxoSYbfW_hoPZEZ8PxFih0e9l3oIMTlYwp1DqA7I_-g-MKK7nN6VJVN6BCtaWDjIe3Znn437RGmMH2G7ncFLgBPKg&_hsmi=373496280&utm_content=372959207&utm_source=hs_email
Aug 2025
Volume 13Number 8p635-722, e11
https://www.thelancet.com/journals/landia/issue/vol13no8/PIIS2213-8587(25)X0008-5
Long-term survival and cure fraction estimates for paediatric central nervous system tumours in 31 European countries (EUROCARE-6): a population-based study +...
https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(25)00297-9/abstract?dgcid=raven_jbs_etoc_feature_lanonc
Editorial
p981
Cancer drug discovery at warp speed: can AI deliver?
The Lancet Oncology
https://www.thelancet.com/journals/lanonc/issue/vol26no8/PIIS1470-2045(25)X0008-5
The OurFutures Vaping eHealth intervention to prevent e-cigarette use among adolescent students in Australia: a cluster randomised controlled trial +...
martes, 29 de julio de 2025
lunes, 28 de julio de 2025
Don’t Forget These Infectious Disease Screenings +++++ ++ +++++
News
Don't Forget These Infectious Disease Screenings
https://www.medscape.com/viewarticle/dont-forget-these-infectious-risk-based-disease-screenings-2025a1000f2o?ecd=mkm_ret_250728_mscpmrk-OUS_InFocus_etid7594337&uac=148436CN&impID=7594337
Europe's Hepatitis A Outbreak: What You Need to Know
https://www.medscape.com/viewarticle/europes-hepatitis-outbreak-what-you-need-know-2025a1000h53?ecd=mkm_ret_250728_mscpmrk-OUS_InFocus_etid7594337&uac=148436CN&impID=7594337
Most Kids Never Get the Cure for Hepatitis C
https://www.medscape.com/viewarticle/clinicians-can-prescribe-cure-hepatitis-c-most-kids-never-2025a1000a42?ecd=mkm_ret_250728_mscpmrk-OUS_InFocus_etid7594337&uac=148436CN&impID=7594337
Does Metabolic Dysfunction Affect Liver Fibrosis in Hep B?
https://www.medscape.com/viewarticle/does-metabolic-dysfunction-associated-steatotic-liver-2025a1000hwa?ecd=mkm_ret_250728_mscpmrk-OUS_InFocus_etid7594337&uac=148436CN&impID=7594337
Preventing Hepatitis B Reactivation: Updated Guidance
https://www.medscape.com/viewarticle/preventing-hepatitis-b-reactivation-updated-clinical-2025a10005oi?ecd=mkm_ret_250728_mscpmrk-OUS_InFocus_etid7594337&uac=148436CN&impID=7594337
Vaccines
Hepatitis A Vaccine Inactivated
https://reference.medscape.com/drug/vaqta-havrix-hepatitis-a-vaccine-inactivated-343150?ecd=mkm_ret_250728_mscpmrk-OUS_InFocus_etid7594337&uac=148436CN&impID=7594337
Hepatitis A/B Vaccine
https://reference.medscape.com/drug/twinrix-hepatitis-a-b-vaccine-343152?ecd=mkm_ret_250728_mscpmrk-OUS_InFocus_etid7594337&uac=148436CN&impID=7594337
Overview & Treatment
Hepatitis A
https://emedicine.medscape.com/article/177484-overview?ecd=mkm_ret_250728_mscpmrk-OUS_InFocus_etid7594337&uac=148436CN&impID=7594337
Hepatitis B
https://emedicine.medscape.com/article/177632-overview?ecd=mkm_ret_250728_mscpmrk-OUS_InFocus_etid7594337&uac=148436CN&impID=7594337
Hepatitis C
https://emedicine.medscape.com/article/177792-overview?ecd=mkm_ret_250728_mscpmrk-OUS_InFocus_etid7594337&uac=148436CN&impID=7594337
Hepatitis D
https://emedicine.medscape.com/article/178038-overview?ecd=mkm_ret_250728_mscpmrk-OUS_InFocus_etid7594337&uac=148436CN&impID=7594337
Hepatitis E
https://emedicine.medscape.com/article/178140-overview?ecd=mkm_ret_250728_mscpmrk-OUS_InFocus_etid7594337&uac=148436CN&impID=7594337
domingo, 27 de julio de 2025
Editorial p827 A commission on vector-borne infections The Lancet Infectious Diseases +...
https://www.thelancet.com/issue/S1473-3099(25)X0008-6
TheLancet.com will undergo maintenance on Sunday July 27th, from approximately, 5.30am to 1.30pm US EST. During this time, some of the site functionality will be paused, we apologise for the inconvenience.
Lay health worker-delivered case management for early episodes of psychosis in Bangkok, Thailand (Lay-CARE): a single-centre, pragmatic, randomised controlled trial
https://www.thelancet.com/journals/lansea/article/PIIS2772-3682(25)00088-5/fulltext?dgcid=hubspot_email_infocusalerts-psychiatry_feature&utm_campaign=infocusalerts-psychiatry&utm_medium=email&_hsenc=p2ANqtz-9BVGMt8rlsLkKctiYPK0V6Uybz6EGOWbgrOZdKoA6qnpVmw-wffbv3C75KdTHYLVOChUFxfTcbAZN8IoicWjrTI7liDg&_hsmi=373110504&utm_content=372952145&utm_source=hs_email
Editorial
Drowning: a preventable crisis in the region
The Lancet Regional Health – Southeast Asia
https://www.thelancet.com/journals/lansea/issue/vol38nonull/PIIS2772-3682(25)X0006-8
TheLancet.com will undergo maintenance on Sunday July 27th, from approximately, 5.30am to 1.30pm US EST. During this time, some of the site functionality will be paused, we apologise for the inconvenience.
Long-acting oral weekly risperidone (LYN-005) for schizophrenia in the USA (STARLYNG-1): a multicentre, open-label, non-randomised phase 3 trial ++...
https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(25)00135-X/fulltext?dgcid=hubspot_email_infocusalerts-psychiatry_feature&utm_campaign=infocusalerts-psychiatry&utm_medium=email&_hsenc=p2ANqtz-8idcQzGPjydfpqEs0VZq_thJNnOB7EF-9XmWxxrWgJpV3XjgXwrU1awouNqOTfGVKQ65SzH3vgvn8pE2fI-CnKwN8kkg&_hsmi=373110504&utm_content=372952145&utm_source=hs_email
Editorial
p475
Division and integration
The Lancet Psychiatry
https://www.thelancet.com/journals/lanpsy/issue/vol12no7/PIIS2215-0366(25)X0007-9
TheLancet.com will undergo maintenance on Sunday July 27th, from approximately, 5.30am to 1.30pm US EST. During this time, some of the site functionality will be paused, we apologise for the inconvenience.
Wenqing Li on transcriptome risk scores to decipher susceptibility genes for risk stratification of gastric cancer July 07, 2025 • The Lancet Group
https://ebiomedicine.buzzsprout.com/1809873/episodes/17429693-wenqing-li-on-transcriptome-risk-scores-to-decipher-susceptibility-genes-for-risk-stratification-of-gastric-cancer?utm_campaign=update-ebiom&utm_medium=email&_hsenc=p2ANqtz---f2hgkwm8tfq0P6AvYry18Ij13RAe5YZYJwpb1NHSSeP0C3H40106HxAGGBYKD39uMe9ZPNI6G5NOAiBT1N884zs2KQ&_hsmi=372659914&utm_content=372380424&utm_source=hs_email
TheLancet.com will undergo maintenance on Sunday July 27th, from approximately, 5.30am to 1.30pm US EST. During this time, some of the site functionality will be paused, we apologise for the inconvenience.
A diet rich in fibre and vegetable protein during gestation and lactation shapes maternal immunity, intestinal microbiota and lipid metabolism
https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(25)00228-2/fulltext?dgcid=hubspot_update_feature_updatealerts_ebiom&utm_campaign=update-ebiom&utm_medium=email&_hsenc=p2ANqtz-9LqISl_9PIC8XeuZ_JyL4_LoPKUa0UN8UYZBVVKVJ4v4Aum3kecGp4P8PxY6ax7pK3UtWsFsFxc0cK4JOwQlO83Uk_eQ&_hsmi=372659914&utm_content=372380424&utm_source=hs_email
TheLancet.com will undergo maintenance on Sunday July 27th, from approximately, 5.30am to 1.30pm US EST. During this time, some of the site functionality will be paused, we apologise for the inconvenience.
Phthalate exposure from plastics and cardiovascular disease: global estimates of attributable mortality and years life lost + +...
https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(25)00174-4/fulltext?dgcid=hubspot_update_feature_updatealerts_ebiom&utm_campaign=update-ebiom&utm_medium=email&_hsenc=p2ANqtz-9n9vRJiSvG1X3KOVaeL9adTxhV1rVQUko6h-OXIsGQhG4dnuhR3r5cKZ-dIwUKGLyMPwEmnRWEI5Jyf2R-9333PhHczg&_hsmi=372659914&utm_content=372380424&utm_source=hs_email
Editorial
The careful use of opioids and alternatives for pain management
eBioMedicine
https://www.thelancet.com/journals/ebiom/issue/vol117nonull/PIIS2352-3964(25)X0006-2
TheLancet.com will undergo maintenance on Sunday July 27th, from approximately, 5.30am to 1.30pm US EST. During this time, some of the site functionality will be paused, we apologise for the inconvenience.
FDA Investigating Death of 8-Year-Old Boy Who Received Elevidys
https://www.fda.gov/news-events/press-announcements/fda-investigating-death-8-year-old-boy-who-received-elevidys?utm_medium=email&utm_source=govdelivery
FDA Investigating Death of 8-Year-Old Boy Who Received Elevidys
The U.S. Food and Drug Administration is investigating the death of an 8-year-old boy who received Elevidys, a Sarepta Therapeutics gene therapy for Duchenne muscular dystrophy. The death occurred on June 7, 2025. The FDA has requested and received voluntary suspension of product distribution as it investigates the safety concerns.
Elevidys is an adeno-associated virus vector-based gene therapy using Sarepta Therapeutics, Inc.’s AAVrh74 Platform Technology for the treatment of Duchenne muscular dystrophy. The product is administered as a single intravenous dose. Duchenne muscular dystrophy is a rare genetic condition characterized by progressive muscular weakness. The disease occurs due to a defective gene.
sábado, 26 de julio de 2025
Research uncovers ME/CFS's systemic impact for targeted therapies +++
https://www.news-medical.net/news/20250726/Research-uncovers-MECFSs-systemic-impact-for-targeted-therapies.aspx
New model predicts mRNA protein production, accelerating drug and vaccine discovery
https://www.news-medical.net/news/20250726/New-model-predicts-mRNA-protein-production-accelerating-drug-and-vaccine-discovery.aspx
Researchers pinpoint PRMT5 as a promising target for cancer drugs
https://www.news-medical.net/news/20250726/Researchers-pinpoint-PRMT5-as-a-promising-target-for-cancer-drugs.aspx
Editorial p625 Accelerating the path towards a cure for Parkinson's disease The Lancet Neurology +...
https://www.thelancet.com/journals/laneur/issue/vol24no8/PIIS1474-4422(25)X0008-9
Safety and efficacy of fenebrutinib in relapsing multiple sclerosis (FENopta): a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial and open-label extension study
Amit Bar-OrMichal DufekHrvoje BudincevicJelena DrulovicMario HabekLe H Huaand others
The Lancet NeurologyVol. 24No. 8p656–666
https://www.thelancet.com/collections/neurology?dgcid=hubspot_email_infocusalerts-neurology_feature&parent=001585&startPage=&ContentItemType=fla&utm_campaign=infocusalerts-neurology&utm_medium=email&_hsenc=p2ANqtz-9HtE8sxUgnm93GBIByy7KsqTc8yPeSLgZuyTXRoJEJI4h6BVDldWMh6DMp_jwbZc0xFRPiAjWQ92t6kZwLNN3h1rxG5g&_hsmi=373022104&utm_content=372951459&utm_source=hs_email
Published: August, 2025
viernes, 25 de julio de 2025
Emergence of Clade Ib Monkeypox Virus - Current State of Evidence Authors: Panayampalli S. Satheshkumar, PhD; Crystal M. Gigante, PhD; Placide Mbala-Kingebeni, MD, MSPH, PhD; Yoshinori Nakazawa, PhD; Mark Anderson, MD, MPH; Stephen Balinandi, MSc, PhD; Sophia Mulei, BS; James Fuller, PhD; Jennifer H. McQuiston, MS, DVM; Andrea M. McCollum, PhD; Christina L. Hutson, MS, PhD
Is There a Role For GLP-1s in Psoriasis? Role of GLP-1 Drugs in Psoriasis Tx ++++++ ++
TRENDING ON PSORIASIS
Re-defining Remission in Plaque Psoriasis
https://www.medscape.com/viewarticle/experts-reach-consensus-defining-treatment-remission-plaque-2025a1000i0g?ecd=WNL_conf_Derm_Psoriasis-GRAPPA-NON-SPON_250725_MSCPEDIT_etid7592345&uac=148436CN&impID=7592345
Current and Future Uses for AI in Dermatology
https://www.medscape.com/viewarticle/current-and-future-uses-ai-dermatology-experts-view-2025a1000f1k?ecd=WNL_conf_Derm_Psoriasis-GRAPPA-NON-SPON_250725_MSCPEDIT_etid7592345&uac=148436CN&impID=7592345
Drug Shows Sustained Improvement of GPP Symptoms
https://www.medscape.com/viewarticle/spesolimab-provides-sustained-improvement-gpp-symptoms-and-2025a1000e5e?ecd=WNL_conf_Derm_Psoriasis-GRAPPA-NON-SPON_250725_MSCPEDIT_etid7592345&uac=148436CN&impID=7592345
Biologic Safety in Psoriasis Patients With Cancer
https://www.medscape.com/viewarticle/il-23-inhibitors-appear-safe-psoriasis-cancer-2025a1000gho?ecd=WNL_conf_Derm_Psoriasis-GRAPPA-NON-SPON_250725_MSCPEDIT_etid7592345&uac=148436CN&impID=7592345
Rethinking Topical Therapy for Psoriasis
https://www.medscape.com/viewarticle/1002116?ecd=WNL_conf_Derm_Psoriasis-GRAPPA-NON-SPON_250725_MSCPEDIT_etid7592345&uac=148436CN&impID=7592345
Volume, Not Price, Drives Derm Drug Costs
https://www.medscape.com/viewarticle/volume-not-price-fueling-rise-part-d-specialty-derm-drug-2025a1000j39?ecd=WNL_conf_Derm_Psoriasis-GRAPPA-NON-SPON_250725_MSCPEDIT_etid7592345&uac=148436CN&impID=7592345
CLINICAL RESOURCES
What Do You Know About Generalized Pustular Psoriasis? Test Your Knowledge
https://reference.medscape.com/viewarticle/fast-five-quiz-what-do-you-know-about-generalized-pustular-2025a1000bai?ecd=WNL_conf_Derm_Psoriasis-GRAPPA-NON-SPON_250725_MSCPEDIT_etid7592345&uac=148436CN&impID=7592345
Painful, Rupturing Lesions in a 40-Year-Old Man: What is Your Dx?
https://reference.medscape.com/viewarticle/painful-rupturing-lesions-40-year-old-man-2025a1000f4s?ecd=WNL_conf_Derm_Psoriasis-GRAPPA-NON-SPON_250725_MSCPEDIT_etid7592345&uac=148436CN&impID=7592345
FOOD MATTERS
Food Matters
By Ivanhoe Broadcast News on July 25, 2025
https://www.ivanhoe.com/family-health/food-matters/
A NEW THERAPY FOR MELANOMA: WHEN ALL ELSE FAILS
A New Therapy for Melanoma: When All Else Fails
By Ivanhoe Broadcast News on July 21, 2025
https://www.ivanhoe.com/family-health/a-new-therapy-for-melanoma-when-all-else-fails/
SCIENTISTS DISCOVER NEW DANGERS OF MICROPLASTICS
Scientists Discover New Dangers of Microplastics
By Ivanhoe Broadcast News on July 22, 2025
https://www.ivanhoe.com/family-health/scientists-discover-new-dangers-of-microplastics/
REWIRING RECOVERY: VIVISTIM FOR STROKE SURVIVORS
Rewiring Recovery: Vivistim for Stroke Survivors
By Ivanhoe Broadcast News on July 24, 2025
https://www.ivanhoe.com/family-health/rewiring-recovery-vivistim-for-stroke-survivors/
HELPING YOUR CHILD BUILD THEIR RESILIENCE MUSCLE
Helping Your Child Build Their Resilience Muscle
By Ivanhoe Broadcast News on August 1, 2025
https://www.ivanhoe.com/?p=35782&preview=1&_ppp=1a4f41bd38
IDEAS FOR US: ECO-ACTION EMPOWERING PEOPLE
IDEAS For Us: Eco-Action Empowering People
By Ivanhoe Broadcast News on July 31, 2025
https://www.ivanhoe.com/?p=35780&preview=1&_ppp=1dab57719d
WHEN HEAT TURNS DEADLY: WHAT PARENTS NEED TO KNOW
When Heat Turns Deadly: What Parents Need to Know
By Ivanhoe Broadcast News on July 30, 2025
https://www.ivanhoe.com/?p=35777&preview=1&_ppp=01b139beba
PLANTING PURPOSE & CULTIVATING CONNECTION
Planting Purpose & Cultivating Connection
By Ivanhoe Broadcast News on July 29, 2025
https://www.ivanhoe.com/?p=35774&preview=1&_ppp=6af5626602
SPOTTING PROSTATE CANCER EARLIER
Spotting Prostate Cancer Earlier
By Ivanhoe Broadcast News on July 28, 2025
https://www.ivanhoe.com/?p=35752&preview=1&_ppp=d73ab44229
jueves, 24 de julio de 2025
Low-gluten diets disrupt gut health by depleting key bacteria
https://www.news-medical.net/news/20250724/Low-gluten-diets-disrupt-gut-health-by-depleting-key-bacteria.aspx
Scientists uncover how long-term gluten reduction, often seen as a health boost, can actually upset gut balance, strip away key microbes, and trigger ethanol build-up tied to inflammation and metabolic risks.
Study reveals pandemic life made brains age faster, even without catching COVID-19
https://www.news-medical.net/news/20250723/Study-reveals-pandemic-life-made-brains-age-faster-even-without-catching-COVID-19.aspx
New research reveals that social isolation and stress during the COVID-19 pandemic accelerated the aging of the brains of older adults, regardless of whether they contracted the virus, highlighting the urgent need for protective strategies beyond infection control.
Rare Disease Focus: Heart Disease +++ +++ +
CLINICAL PERSPECTIVES
Marfan Syndrome: Diagnosis and Management
https://checkrare.com/marfan-syndrome-diagnosis-and-management/
David Liang, MD, PhD, Cardiologist at Hoag Hospital, discusses the diagnosis and management of Marfan syndrome.
Evolving Policy Landscapes for Rare Disease Access
https://checkrare.com/evolving-policy-landscapes-for-rare-disease-access/
Deb Jennings, Head of North America Patient Services Operations at Kyowa Kirin, discusses evolving policy landscapes for rare disease access.
The Role of Mental Health in Rare Disease Patient Outcomes
https://checkrare.com/the-role-of-mental-health-in-rare-disease-patient-outcomes/
Sumira Riaz, PhD, Health Psychologist & Patient Engagement Consultant at Unboxed Psychology, discusses the role of mental health in rare disease patient outcomes.
Disease Severity and Progression in Patients With ENPP1 Deficiency
https://checkrare.com/disease-severity-and-progression-in-patients-with-enpp1-deficiency/
Matt Winton, PhD, Senior Vice President and Chief Operating Officer of Inozyme Pharma, discusses results from an analysis characterizing disease severity and progression in patients with ENPP1 deficiency.
The Undiagnosed Disease Network
https://checkrare.com/the-undiagnosed-disease-network/
Kimberly LeBlanc, Genetic Counselor, Director of the Undiagnosed Diseases Network (UDN) Coordinating Center at Harvard Medical School, discusses approaching variants of uncertain significance in rare diseases.
Ethical Concerns in Rare Diseases and Expanded Access Programs
https://checkrare.com/ethical-concerns-in-rare-diseases-and-expanded-access-programs/
Alison Bateman-House, PhD, Assistant Professor Division of Medical Ethics at NYU Grossman School of Medicine, discusses ethical concerns in rare diseases and expanded access programs.
The Diversity of Patient Advocacy Group Initiatives
https://checkrare.com/the-diversity-of-patient-advocacy-group-initiatives/
Connie Lee, PsyD, Chief Executive Officer of Alliance to Cure Cavernous Malformations, discusses cerebral cavernous malformation (CMM) and the diversity of patient advocacy group initiatives.
The global landscape and development pipeline for childhood cancer medicines: a comprehensive analysis with dashboard generation +...
https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(25)00142-7/abstract?utm_campaign=update-lanchi&utm_medium=email&dgcid=hubspot_update_feature_updatealerts_lanchi&_hsenc=p2ANqtz-__QKaBPTCgE5OrCNkibfyad1p9G1PjyPQ3xANjT0q_G9ndQi_P983dKRTwwC7AVlBtODsIDeaiCq8bRjIjvdbUaG9vgw&_hsmi=372642248&utm_content=372379837&utm_source=hs_email
Editorial
p519
Research-driven neonatology for equitable neonatal health
The Lancet Child & Adolescent Health
https://www.thelancet.com/journals/lanchi/issue/vol9no8/PIIS2352-4642(25)X0008-0
The Lancet Child & Adolescent Health Commission on the future of neonatology
https://www.thelancet.com/commissions-do/future-neonatology?dgcid=hubspot_update_feature_lanchineonatalrd25&utm_campaign=update-lanchi&utm_medium=email&_hsenc=p2ANqtz-8n6JVObgK59dJ1sqVxJJjBpoWuGpXqt1xrgy8aNSazIUzPMD2aei0GHlxoLu8hGZ63pdJWw3Ecw5z58HM8iGIprPztWg&_hsmi=372642248&utm_content=372379837&utm_source=hs_email
Trends and predictions to 2030 in demographic structures and metabolic health for children and adolescents in China: analysis of national school health surveys from 2000 to 2019
https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(25)00140-3/abstract?utm_campaign=update-lanchi&utm_medium=email&dgcid=hubspot_update_feature_updatealerts_lanchi&_hsenc=p2ANqtz-_oV3jp8EXDg9zsj_IndINFHE4gjBmWJ1Y-3gT6Y3p7Ayvp7e7eiuHWEf0plC_9NK8Efds5-5b4dpfZZrzNVEIGVFQeGA&_hsmi=372642248&utm_content=372379837&utm_source=hs_email
A commission on vector-borne infections The Lancet Infectious Diseases +...
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00430-X/fulltext?dgcid=raven_jbs_etoc_email
Issue cover for Volume 25, Issue 8
Aug 2025
Volume 25Number 8p827-946, e439-e490
https://www.thelancet.com/journals/laninf/issue/vol25no8/PIIS1473-3099(25)X0008-6
Immunogenicity and safety of an Escherichia coli-produced bivalent human papillomavirus vaccine (Cecolin) in girls aged 9–14 years in Ghana and Bangladesh: a randomised, controlled, open-label, non-inferiority, phase 3 trial
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00031-3/fulltext?dcig=raven_jbs_etoc_feature_laninf
miércoles, 23 de julio de 2025
'Western diet' blamed for growing risk of GI cancers among young adults By Ashley J. DiMella Fox News Published July 16, 2025 8:36am EDT
'Western diet' blamed for growing risk of GI cancers among young adults
Processed meats, sugary drinks and refined grains identified as potential risk factors
Ashley J. DiMella By Ashley J. DiMella Fox News
Published July 16, 2025 8:36am EDT
https://www.foxnews.com/health/western-diet-blamed-growing-risk-gi-cancers-among-young-adults
Texas psychiatrist reveals mental health challenges facing flood disaster survivors By Rachel Wolf Fox News Published July 16, 2025 12:19pm EDT
Texas psychiatrist reveals mental health challenges facing flood disaster survivors
'The reality for these families is that once the camera crews are gone and once the aid organizations are packing up, they’re still going to be living with the repercussions of this,' Dr. Browne said
Rachel Wolf By Rachel Wolf Fox News
Published July 16, 2025 12:19pm EDT
https://www.foxnews.com/health/texas-psychiatrist-reveals-mental-health-challenges-facing-flood-disaster-survivors
Here's what marijuana really does to the developing brain, according to a psychiatrist By Angelica Stabile Fox News Published July 18, 2025 2:58pm EDT
Here's what marijuana really does to the developing brain, according to a psychiatrist
Cognitive specialist Dr. Amen warns that cannabis can age the brain and cause mental health issues
Angelica Stabile By Angelica Stabile Fox News
Published July 18, 2025 2:58pm EDT
https://www.foxnews.com/health/heres-what-marijuana-really-does-developing-brain-according-psychiatrist
Alzheimer's risk could rise with specific sleep pattern, experts warn By Angelica Stabile Fox News Published July 21, 2025 5:00am EDT
Alzheimer's risk could rise with specific sleep pattern, experts warn
Delayed REM sleep may indicate cognitive decline, study suggests
Angelica Stabile By Angelica Stabile Fox News
Published July 21, 2025 5:00am EDT
https://www.foxnews.com/health/alzheimers-risk-could-rise-specific-sleep-pattern-experts-warn
Higher cancer rates linked to WWII radioactive waste in Midwestern creek By Angelica Stabile Fox News Published July 22, 2025 5:07pm EDT
Higher cancer rates linked to WWII radioactive waste in Midwestern creek
Missouri's Coldwater Creek leaves lasting health legacy for those who grew up there
Angelica Stabile By Angelica Stabile Fox News
Published July 22, 2025 5:07pm EDT
https://www.foxnews.com/health/higher-cancer-rates-linked-wwii-radioactive-waste-midwestern-creek
Children's National Hospital in DC to end gender transition medical interventions By Danielle Wallace Fox News Published July 21, 2025 8:57am EDT
Children's National Hospital in DC to end gender transition medical interventions
Children's National cites 'escalating legal and regulatory risks' as Justice Department investigates pediatric transgender procedures
Danielle Wallace By Danielle Wallace Fox News
Published July 21, 2025 8:57am EDT
https://www.foxnews.com/health/childrens-national-hospital-dc-end-gender-transition-medical-interventions
Experts reveal 5-step approach to a healthier gut and stronger immunity By Amy McGorry Fox News Published July 17, 2025 5:00am EDT
Experts reveal 5-step approach to a healthier gut and stronger immunity
Medical experts reveal how the '5R' plan can boost immunity and reduce inflammation
By Amy McGorry Fox News
Published July 17, 2025 5:00am EDT
https://www.foxnews.com/health/experts-reveal-5-step-approach-healthier-gut-stronger-immunity
Eating foods in this order could help with weight loss and blood sugar, experts say By Amy McGorry Fox News Published July 20, 2025 4:23pm EDT
Eating foods in this order could help with weight loss and blood sugar, experts say
‘Meal sequencing’ technique has been shown to benefit those with diabetes
By Amy McGorry Fox News
Published July 20, 2025 4:23pm EDT
https://www.foxnews.com/health/eating-foods-order-could-help-weight-loss-blood-sugar-experts-say
E21 Inclusion of Pregnant and Breastfeeding Women in Clinical Trials Draft Guidance for Industry July 2025
https://www.fda.gov/regulatory-information/search-fda-guidance-documents/e21-inclusion-pregnant-and-breastfeeding-women-clinical-trials?utm_medium=email&utm_source=govdelivery
Download the draft guidance document (PDF, 430KB)
https://www.fda.gov/media/187755/download?utm_medium=email&utm_source=govdelivery
Man's deadly brain cancer tumor disappears after experimental drug trial Two years after treatment with ipilimumab, patient shows no signs of glioblastoma Melissa Rudy By Melissa Rudy Fox News Published July 22, 2025 5:00am EDT
Man's deadly brain cancer tumor disappears after experimental drug trial
Two years after treatment with ipilimumab, patient shows no signs of glioblastoma
Melissa Rudy By Melissa Rudy Fox News
Published July 22, 2025 5:00am EDT
https://www.foxnews.com/health/mans-deadly-brain-cancer-tumor-disappears-after-experimental-drug-trial
Never enter an MRI machine with any of these hazardous items, experts warn New York man's death highlights critical MRI safety protocols Angelica Stabile By Angelica Stabile Fox News Published July 21, 2025 3:27pm EDT
Never enter an MRI machine with any of these hazardous items, experts warn
New York man's death highlights critical MRI safety protocols
Angelica Stabile By Angelica Stabile Fox News
Published July 21, 2025 3:27pm EDT
https://www.foxnews.com/health/never-enter-mri-machine-any-hazardous-items-experts-warn?lid=zncn76nmijkl
The impact of living with a rare disease: barriers and enablers of independent living and social participation +++
https://www.eurordis.org/publications/rb-dailylife-report/
EURORDIS responds to European Commission’s proposed 2028-34 budget
July 2025
17 July 2025, Brussels – The European Commission has unveiled its long-term budget proposal for the 2028–2034 Multiannual Financial Framework (MFF). The proposal sets out the Union’s roughly €1.8 trillion budget and spending priorities for the seven-year period, including investments in competitiveness, social cohesion, public health, and research.
https://www.eurordis.org/eurordis-responds-to-eu-commissions-proposed-2028-34-budget/
Recognising the disabilities of those living with rare diseases
July 2025
Between July and September 2024, EURORDIS–Rare Diseases Europe’s Rare Barometer programme carried out one of the widest-reaching surveys to date on the intersection between rare diseases and disability.
https://www.eurordis.org/recognising-rare-disease-disabilities/
Beyond Baby KJ: Next Steps in Manufacturing Genome Editing Cures Wednesday, July 30, 2025 9:00 am PT, 12:00 pm ET, 18:00 CEST
https://www.genengnews.com/multimedia/beyond-baby-kj-next-steps-in-manufacturing-genome-editing-cures/?utm_campaign=15735301-GEN_GEN_Live_20250730&utm_medium=email&_hsenc=p2ANqtz-_xvOAUKG2p4KdRdbi2NsfE8bof_3qboBP99tJfi8mWve8-JVTuRpbYdxUpvspPy11laT-IBX4khaJicE_RjumSQeD6IQ&_hsmi=372453060&utm_content=372400580&utm_source=hs_email
Last month, for the first time, a baby with a rare genetic disorder known as “Baby KJ” was treated with a gene-editing therapy tailored to his rare mutation. The milestone made headlines—and marked a win for the genome editing field, offering new promise for the future of genomic medicine.
But there is another layer to the story: how the treatment was manufactured. Developing a single, personalized therapy required a coordinated sprint from teams at IDT, Aldevron, and Danaher, working under intense pressure to produce the gene-editing payload and its delivery system. Now, the real challenge lies ahead—delivering treatments like this to more patients. On this GEN Live, we take a close look at the work behind this successful treatment and perhaps more importantly, we explore how this can be done on a larger scale in the future. We will discuss the challenges that lie ahead, including scale and cost, and how some companies are thinking about solving those.
martes, 22 de julio de 2025
The evolving treatment landscape in Still's disease The Lancet Rheumatology + + +...
https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(25)00192-4/fulltext?dgcid=raven_jbs_etoc_email
Aug 2025
Volume 7Number 8e521-e590
https://www.thelancet.com/journals/lanrhe/issue/vol7no8/PIIS2665-9913(25)X0008-4
Sarilumab in relapsing polymyalgia rheumatica: patient-reported outcomes from a phase 3, double-blind, randomised controlled trial
https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(25)00041-4/abstract?dgcid=raven_jbs_etoc_feature_lanrhe
lunes, 21 de julio de 2025
Insurance-Survival Gap Growing in Immunotherapy Era Edited by Gargi Mukherjee July 21, 2025 ++++
https://www.medscape.com/viewarticle/insurance-survival-gap-growing-immunotherapy-era-2025a1000j7e
Safe to Skip Postop Radioiodine in Most Low-Risk Thyroid Cancers
Edited by Gargi Mukherjee
https://www.medscape.com/viewarticle/safe-skip-postop-radioiodine-most-low-risk-thyroid-cancers-2025a1000j7z
July 21, 2025
FDA Advisory Panel Votes NO on Belantamab for Myeloma
Sharon Worcester
https://www.medscape.com/viewarticle/fda-advisory-panel-votes-no-belantamab-myeloma-2025a1000j6y
July 21, 2025
The Impact of Prevention, Screening, and Treatment on Cancer Death Reduction
Maurie Markman, MD
https://www.medscape.com/viewarticle/impact-prevention-screening-and-treatment-cancer-death-2025a1000i47
| July 21, 2025
Total Neoadjuvant Therapy Shows Consistent Efficacy Across Different Regimens in Locally Advanced Rectal Cancer Edited by Gargi Mukherjee Medscape UK article logo July 21, 2025Total Neoadjuvant Therapy Shows Consistent Efficacy Across Different Regimens in Locally Advanced Rectal Cancer Edited by Gargi Mukherjee Medscape UK July 21, 2025
Post-traumatic stress disorder in older adults: a global collaboration on setting the future research agenda +...
https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(25)00039-X/fulltext?dgcid=hubspot_update_feature_updatealerts_lanhl&utm_campaign=update-lanhl&utm_medium=email&_hsenc=p2ANqtz-_AUFdG_mUV75DdMdCWzHm2ota1-bj-t6qvI-v8ralXQFgP9dB2bnr3zdgc-bU2VOVR_pm2DSp4t5kIpsahKl4YXQG3LA&_hsmi=372138574&utm_content=371908342&utm_source=hs_email
Editorial
Adult social care: insufficient funding and financial pressures
The Lancet Healthy Longevity
https://www.thelancet.com/journals/lanhl/issue/vol6no6/PIIS2666-7568(25)X0007-6
Blocking GAPDH aggregation protects brain cells and opens new path for stroke therapy
https://www.news-medical.net/news/20250720/Blocking-GAPDH-aggregation-protects-brain-cells-and-opens-new-path-for-stroke-therapy.aspx
A novel study reveals that targeting a single protein’s aggregation can dramatically reduce brain injury after stroke, potentially transforming how acute ischemic strokes are treated.
Can probiotics help you sleep better?
Could the key to better sleep and brighter mood lie in your gut? New research suggests probiotic supplements may safely ease insomnia and depressive symptoms, but more studies are needed to pinpoint who benefits most.
https://www.news-medical.net/news/20250720/Can-probiotics-help-you-sleep-better.aspx
Erythritol alters brain vessel function and may raise stroke risk
Scientists show how a common zero-calorie sweetener found in many diet drinks may harm the brain's vascular system by increasing oxidative stress and impairing vital blood vessel functions.
https://www.news-medical.net/news/20250721/Erythritol-alters-brain-vessel-function-and-may-raise-stroke-risk.aspx
Meat hummus lowers microbes and raises nutrition
https://www.news-medical.net/news/20250721/Meat-hummus-lowers-microbes-and-raises-nutrition.aspx
Scientists show that lamb-infused hummus packs more protein, iron, and flavor while staying fresher, offering flexitarians and athletes a nutrient-rich twist on the classic dip.
Transforming women's health, empowerment, and gender equality with digital health: evidence-based policy and practice +++
https://www.thelancet.com/journals/landig/article/PIIS2589-7500(25)00022-6/fulltext?dgcid=hubspot_update_feature_updatealerts_landig&utm_campaign=update-landig&utm_medium=email&_hsenc=p2ANqtz--y5ThKdmWsr522dF72AL_HTJbq6BQLghLVx067Hfs4CdoO6FtT06YV6ykdWhAz9M27CBObVS4GbPDk2E_EsY_jRG0omA&_hsmi=371433429&utm_content=371147702&utm_source=hs_email
Jun 2025
Volume 7Number 6
https://www.thelancet.com/journals/landig/issue/vol7no6/PIIS2589-7500(25)X0006-6
Online video versus face-to-face preoperative consultation for major abdominal surgery (VIDEOGO): a multicentre, open-label, randomised, controlled, non-inferiority trial
https://www.thelancet.com/journals/landig/article/PIIS2589-7500(25)00039-1/fulltext?dgcid=hubspot_update_feature_updatealerts_landig&utm_campaign=update-landig&utm_medium=email&_hsenc=p2ANqtz-8REhcdwvhQxPfkrt9Xrf7erAQmpeV3uo94nXGv_kA9pzHECWZXfjpIf34i25411v1ryQLKNb74de8_DALxXb58E4pqPA&_hsmi=371433429&utm_content=371147702&utm_source=hs_email
Evolving patterns of macrolide and fluoroquinolone resistance in Mycoplasma genitalium: an updated systematic review and meta-analysis ++
https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(24)00315-X/fulltext?dgcid=hubspot_update_feature_updatealerts_lanmic&utm_campaign=update-lanmic&utm_medium=email&_hsenc=p2ANqtz-_65tQBVHjkPN9CbWHkEzFhGGT5ZjJfzReQ--Y61eZi0P_nrmEG-vR9sKVFImkqGAsGNCMTXEoSDjiC8stWQGRd-lFkAw&_hsmi=371442107&utm_content=371147167&utm_source=hs_email
Population-level impact of mass drug administration against schistosomiasis with anthelmintic drugs targeting juvenile schistosomes: a modelling study
https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(24)00333-1/fulltext?dgcid=hubspot_update_feature_updatealerts_lanmic&utm_campaign=update-lanmic&utm_medium=email&_hsenc=p2ANqtz-8ypR31Xo2ALEiGgxfIcgPLJ7siNMkOYHErxCU_joLFUUUPm2Hz4YqoTQ6p8djJ8UWCtosJJpVTbEGDVJbK1R-hdR5qUQ&_hsmi=371442107&utm_content=371147167&utm_source=hs_email
Performance of stool Xpert MTB/RIF Ultra for detection of Mycobacterium tuberculosis among adults living with HIV: a multicentre, prospective diagnostic study +...
https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(25)00013-8/fulltext?dgcid=hubspot_update_feature_updatealerts_lanmic&utm_campaign=update-lanmic&utm_medium=email&_hsenc=p2ANqtz-9qmLr_-bEUj7hWlqi91ZBC13uNxXw4kmykZqoaB5ZslDbUq3gif308MpPJQ0_awqw8uWiR47PYDMs-Q2XbVW-NFZRE9w&_hsmi=371442107&utm_content=371147167&utm_source=hs_email
Editorial
Overcoming the dilemma of dengue diagnostics
The Lancet Microbe
https://www.thelancet.com/journals/lanmic/issue/vol6no7/PIIS2666-5247(25)X0007-0
domingo, 20 de julio de 2025
Fast Facts: Inflammatory Bowel DiseaseFree By David S. Rampton; Fergus Shanahan
https://karger.com/books/book/6019/Fast-Facts-Inflammatory-Bowel-Disease?utm_source=email&utm_medium=external&utm_campaign=azo_newsletter_gastro
The seventh edition of Fast Facts: Inflammatory Bowel Disease offers an updated overview of Crohn’s disease and ulcerative colitis, highlighting microbiome research and evolving treatment strategies. It covers the use of immunomodulators, biologics, and emerging therapies. Designed for non-specialist doctors, nurses, dietitians, and other healthcare professionals, this concise guide supports those involved in the care of patients with IBD.
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