She’s hellbent on solving the organ shortage with ‘designer pigs.’ Just don’t keep her waiting Sharon Begley By Sharon Begley

https://www.statnews.com/2017/04/06/crispr-pig-organs-transplant-luhan-yang/?utm_campaign=morning_rounds&utm_medium=email&_hsmi=290577490&_hsenc=p2ANqtz-88p43AuI1eKGqEOZFyq1XvWFhsQo200SBSn03L5us-U5OyuODkTqUdK-FSVJCAKmHMXU4JGYw2bCgNmUFO1pgzwl5Fqw&utm_content=290577490&utm_source=hs_email When I hear about eGenesis, a pioneer in xenotransplantation deploying CRISPR to edit viruses out of pig organs, I think of its mission to solve the shortage of organs. That’s still its goal, but now the company is working with researchers at Penn Medicine to use human-friendly pig organs as a bridge for critically ill patients waiting to get better or to receive a human transplant. The technique is called extracorporeal perfusion and it circulates a patient’s blood through a genetically engineered pig organ kept alive in an incubator. Yesterday researchers said the procedure passed its first test in a brain-dead human. STAT’s Megan Molteni describes it as “kind of like dialysis, except the guts of the machine are literal guts, from a pig.” Mike Curtis, eGenesis's CEO, told her “it’s not xenotransplant, but it’s a technology and a product that can fulfill a huge unmet need.” Caveat: Data from this experiment have not been published or made available as a preprint. Read more. https://www.statnews.com/2024/01/18/egenesis-crispr-pig-liver-tested-in-brain-dead-patient/?utm_campaign=morning_rounds&utm_medium=email&_hsmi=290577490&_hsenc=p2ANqtz-8JHU0UepejBlmeMYPBy9TzCRKn44trGmyRYIliNdWlKi5NUP-4GHIh-MwRpLsP1nUnDsB6vRYLvCGYlMi2CLsttB4j6A&utm_content=290577490&utm_source=hs_email