Circular RNA in cancer: functions and clinical implications

Circular RNA in cancer: Functions and clinical implications

Cancer Cell International is seeking papers for a thematic series on circular RNA.

Circular RNA (circRNA) is a type of covalently closed non-coding RNA that stems from the non-canonical splicing of linear pre-mRNAs. Emerging evidence indicates that circRNAs play multifaceted roles in carcinogenesis, e.g., as oncogenic stimuli or tumor suppressors in cancers. circRNAs have also been shown to be enriched and stable in extracellular fluid, indicating the potential of circRNAs as cancer biomarkers. Furthermore, circRNA, together with its gene silencing ability, also shows its potential in RNA interference (RNAi) therapy by binding to target RNAs, which provides a novel perspective in cancer treatment. In this thematic series, we will include studies regarding the classification, biogenesis, properties, functions and clinical implications of circRNA in cancer. 

This thematic series will be comprised of original articles and review articles to highlight recent advances in circRNA in cancer. All the submitted manuscripts will be subjected to independent reviewers and those of low priority will be rejected. 

Potential topics of interest include but are not limited to: 

1. The role of circRNAs in cancer initiation and progression; 
2. The potential of circRNAs as biomarkers for cancer diagnosis and/or prognosis;
3. The potential of circRNAs as therapeutic targets for cancer.

The submission deadline for the thematic series is December 31st, 2020. Submissions can be made through the journal's Editorial Manager system.

© Chee-Onn Leong

1. CircRNA_104889 promotes lung adenocarcinoma cell invasion via sponging miR4458

   Lung adenocarcinoma is metastatic cancer with a high mortality rate. Circular RNAs (circRNAs) are a type of noncoding RNA and play a vital role in cancer progression. However, the expression and function of ci...

   Authors:Yongyong Yan, Jiantian Yang, Janak L. Pathak, Haiyan Wang, Jun Zha, Yongxiang Wei, Haibo Tang and Linhu Ge

   Citation:Cancer Cell International 2020 20:432

   Content type:Primary research

    

   Published on: 3 September 2020

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2. Circ_0004913 sponges miR-1290 and regulates FOXC1 to inhibit the proliferation of hepatocellular carcinoma

   Circular RNA (circRNA), an novel type of non-coding RNA, could interact with miRNA and protein molecules to regulate the occurrence and progression of hepatocellular carcinoma (HCC). However, little is known a...

   Authors:Yabin Yu, Suyang Han, Meng Li, Yan Song and Fuzhen Qi

   Citation:Cancer Cell International 2020 20:431

   Content type:Primary research

    

   Published on: 3 September 2020

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3. Identification of circular RNA hsa_circ_0044556 and its effect on the progression of colorectal cancer

   Circular RNAs (circRNAs) are a novel class of noncoding RNAs. Increasing evidence indicates that circRNAs play an important role in the occurrence and development of tumors. However, the role of circRNA hsa_ci...

   Authors:Liang Jing, Junhui Wu, Xiaocheng Tang, Min Ma, Fei Long, Buning Tian and Changwei Lin

   Citation:Cancer Cell International 2020 20:427

   Content type:Primary research

    

   Published on: 1 September 2020

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4. Circular RNAs and esophageal cancer

   As a new kind of RNA, circular RNA (circRNA) is a endogenous non-coding RNA with circular structure, which has the characteristics of universality, stability, conservatism and specificity. CircRNA can specific...

   Authors:Xiaoqing Zhang, Ning Lu, Li Wang, Yixuan Wang, Minna Li, Ying Zhou, Honglin Yan, Manli Cui, Mingxin Zhang and Lingmin Zhang

   Citation:Cancer Cell International 2020 20:362

   Content type:Review

    

   Published on: 3 August 2020

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5. The emerging roles of circular RNAs in ovarian cancer

   Circular RNA (circRNA) is a novel class of regulatory noncoding RNA (ncRNA) molecules with a unique covalently closed loop structure. Next-generation sequencing shows that thousands of circRNAs are widely and ...

   Authors:Xuejing Yang, Jie Mei, Huiyu Wang, Dingyi Gu, Junli Ding and Chaoying Liu

   Citation:Cancer Cell International 2020 20:265

   Content type:Review

    

   Published on: 23 June 2020

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6. Serum-derived three-circRNA signature as a diagnostic biomarker for hepatocellular carcinoma

   Hepatocellular carcinoma (HCC) is a common tumor characterized by high morbidity and mortality rates. The importance of circRNA in cancer diagnosis has been established. The study aimed to identify differentia...

   Authors:Xiang-Hong Sun, Yu-Tong Wang, Guo-Fu Li, Nan Zhang and Ling Fan

   Citation:Cancer Cell International 2020 20:226

   Content type:Primary research

    

   Published on: 10 June 2020

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7. Circular RNA and tumor microenvironment

   Circular RNAs (circRNAs) are small non-coding RNAs with a unique ring structure and play important roles as gene regulators. Disturbed expressions of circRNAs is closely related to varieties of pathological pr...

   Authors:Huixin Song, Qiaofei Liu and Quan Liao

   Citation:Cancer Cell International 2020 20:211

   Content type:Review

    

   Published on: 3 June 2020

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8. Oncogenic role of HMGA2 in fusion-negative rhabdomyosarcoma cells

   Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma. There are two subtypes, fusion gene-positive RMS (FP-RMS) and fusion gene-negative RMS (FN-RMS), depending on the presence of a fusion g...

   Authors:Kazutaka Ouchi, Mitsuru Miyachi, Shigeki Yagyu, Ken Kikuchi, Yasumichi Kuwahara, Kunihiko Tsuchiya, Tomoko Iehara and Hajime Hosoi

   Citation:Cancer Cell International 2020 20:192

   Content type:Primary research

    

   Published on: 24 May 2020

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9. Identification and validation of an individualized autophagy-clinical prognostic index in gastric cancer patients

   The purpose of this study is to perform bioinformatics analysis of autophagy-related genes in gastric cancer, and to construct a multi-gene joint signature for predicting the prognosis of gastric cancer.

   Authors:Jieping Qiu, Mengyu Sun, Yaoqun Wang and Bo Chen

   Citation:Cancer Cell International 2020 20:178

   Content type:Primary research

    

   Published on: 20 May 2020

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10. Identification of novel biomarkers affecting the metastasis of colorectal cancer through bioinformatics analysis and validation through qRT-PCR

    Tumor progression and distant metastasis are the main causes of deaths in colorectal cancer (CRC) patients, and the molecular mechanisms in CRC metastasis have not been completely discovered.

    Authors:Wenping Lian, Huifang Jin, Jingjing Cao, Xinyu Zhang, Tao Zhu, Shuai Zhao, Sujun Wu, Kailu Zou, Xinyun Zhang, Mingliang Zhang, Xiaoyong Zheng and Mengle Peng

    Citation:Cancer Cell International 2020 20:105

    Content type:Primary research

     

    Published on: 30 March 2020

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11. Circular RNA circVAPA knockdown suppresses colorectal cancer cell growth process by regulating miR-125a/CREB5 axis

    Colorectal cancer (CRC) is a malignant tumor, and the overall prognosis of patients with advanced CRC is still unsatisfactory. Circular RNAs (circRNAs) vesicle-associated membrane protein-associated protein A ...

    Authors:Xiaoyu Zhang, Yingying Xu, Kenji Yamaguchi, Jinping Hu, Lianbo Zhang, Jianfeng Wang, Jifeng Tian and Wanying Chen

    Citation:Cancer Cell International 2020 20:103

    Content type:Primary research

     

    Published on: 30 March 2020

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12. M2 bone marrow-derived macrophage-derived exosomes shuffle microRNA-21 to accelerate immune escape of glioma by modulating PEG3

    Growing studies have focused on the role of microRNA-21 (miR-21) in glioma, thus our objective was to discuss the effect of M2 bone marrow-derived macrophage (BMDM)-derived exosomes (BMDM-Exos) shuffle miR-21 ...

    Authors:Fan Yang, Tiecheng Wang, Peng Du, Haitao Fan, Xushuai Dong and Hua Guo

    Citation:Cancer Cell International 2020 20:93

    Content type:Primary research

     

    Published on: 27 March 2020

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13. Circ_0008035 contributes to cell proliferation and inhibits apoptosis and ferroptosis in gastric cancer via miR-599/EIF4A1 axis

    Currently, multiple circular RNAs (circRNAs) have been verified to act as essential regulators in the progression of gastric cancer (GC). We aimed to investigate the role of circ_0008035 in GC progression.

    Authors:Chang Li, Yuan Tian, Yun Liang and Qingchun Li

    Citation:Cancer Cell International 2020 20:84

    Content type:Primary research

     

    Published on: 16 March 2020

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14. CircPIP5K1A facilitates gastric cancer progression via miR-376c-3p/ZNF146 axis

    Recently, many emerging circular RNAs (circRNAs) have been studied in human malignancies, including gastric cancer (GC). Researches concerning cancers have revealed that aberrant expression of circRNAs play a ...

    Authors:Yan Ma, Xiliang Cong, Yiyun Zhang, Xin Yin, Ziyu Zhu and Yingwei Xue

    Citation:Cancer Cell International 2020 20:81

    Content type:Primary research

     

    Published on: 14 March 2020

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15. Construction of a circRNA-miRNA-mRNA network based on competitive endogenous RNA reveals the function of circRNAs in osteosarcoma

    Osteosarcoma (OS) is a common primary malignant bone tumour. Growing evidence suggests that circular RNAs (circRNAs) are closely related to the development of tumours. However, the function of circRNAs in OS r...

    Authors:Yu Qiu, Chao Pu, Yanchao Li and Baochuang Qi

    Citation:Cancer Cell International 2020 20:48

    Content type:Primary research

     

    Published on: 10 February 2020

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16. Identification of a potentially functional circRNA–miRNA–mRNA regulatory network for investigating pathogenesis and providing possible biomarkers of bladder cancer

    Circular RNAs (circRNAs) have received considerable attention in human cancer research. However, many circRNAs remain to be detected. In our study, we determined novel circRNAs and investigated their effects o...

    Authors:Hong-cheng Lu, Jia-qi Yao, Xiao Yang, Jie Han, Jing-zi Wang, Kun Xu, Rui Zhou, Hao Yu, Qiang Lv and Min Gu

    Citation:Cancer Cell International 2020 20:31

    Content type:Primary research

     

    Published on: 29 January 2020

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