domingo, 26 de abril de 2020

The Challenge of Tracking COVID-19’s Stealthy Spread NIH Director's Blog, April 23, 2020

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Coronavirus
The Challenge of Tracking COVID-19’s Stealthy Spread
NIH Director's Blog, April 23, 2020
This include four key priorities. The first involves improving fundamental knowledge of virus including studies to characterize the virus and better understand how it causes infection and disease. This includes natural history, transmission studies to determine why some individuals experience mild symptoms while others become critically ill.
Identification of super-transmitters of SARS-CoV-2
X Yang et al, MEDRXIV, April 23, 2020
Four genetic clusters defined as Super-transmitters (STs) were found to become dominant and were responsible for the major outbreaks in various countries.
In this study, we used population genetics analysis to infer the mutation rate and plausible recombination events that may have contributed to the evolution of the SARS-CoV-2 virus. Furthermore, we localized targets of recent and strong positive selection.
Ethnic minority groups have been disproportionately affected by covid-19 in the US, highlighting potential racial, economic, and other inequalities.

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