CIENCIASMEDICASNEWS: Medical News | Medical Articles: Streamlining the Antibody Discovery Workflow at ModiQuest Research

lunes, 28 de octubre de 2019

Medical News | Medical Articles: Streamlining the Antibody Discovery Workflow at ModiQuest Research

	October 28, 2019
	Immunology
	The latest immunology news from News Medical

Appliction Note: Streamlining the Antibody Discovery Workflow at ModiQuest Research

Breakthroughs in molecular engineering and antibody humanization, have resulted in monoclonal antibodies (mAbs) becoming one of the fastest-growing classes of biopharmaceuticals for multiple clinical indications.

This highly competitive landscape necessitates the need for rapidly developing next generation antibodies against new challenging targets with improved mechanism of action, pharmacokinetics and delivery system.

Current antibody screening tools such as ELISA only report on binding, one antigen at a time, hence they are time consuming and utilize large amounts of target protein. This application note highlights how the Intellicyt^® iQue Screener platform enabled scientists at ModiQuest Research to significantly reduced their lead discovery time while conserving valuable samples and cutting down reagent cost.

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What are you missing with MMR by IHC testing alone?

IHC can miss up to 10% of dMMR tumor samples. Current guidelines recommend co-testing tumor samples using both MSI by PCR and MMR by IHC, decreasing the number of mischaracterized tumor samples to less than 1%.

Find Out More

Study highlights the need to better understand immunity against mumps virus

Immunity against mumps virus appears insufficient in a fraction of college-aged people who were vaccinated in childhood, research from Emory Vaccine Center and the Centers for Disease Control and Prevention indicates.

	Researchers analyze people’s initial immune response to dengue fever Researchers have come one step closer to understanding how our immune system responds to acute dengue fever, a disease that has affected hundreds of thousands of people in Southeast Asia this summer alone.

	Study reveals insights into new populations of immune cells in the lungs Due to their function, the lungs are constantly exposed to various compounds carried in the air, sometimes harmful, sometimes harmless.

	Pneumonia uses hydrogen peroxide to weaken the immune system Pneumonia is a lung infection, filling up the alveoli with pus and fluid. At present, it’s the leading cause of death among children. The lung infection accounts for 15 percent of all deaths in children below five years old, killing more than 800,000 children in 2017 alone.

	Uncovering new T cell regulatory processes could help treat autoimmune disease One of the important cells involved in the immune response is the T follicular helper (Tfh) cell. These are important in the normal process of antibody production following immunization, for instance. However, they are also abnormally increased in number in patients with autoimmune disease, such as systemic lupus erythematosus.