Childhood Vascular Tumors Treatment (PDQ®)–Health Professional Version

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Changes to this Summary (12/21/2017)

The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

Benign Tumors

Added text to state that permanent sequelae, such as telangiectasia, anetodermal skin, redundant skin, and a persistent superficial component, can occur after hemangioma involution. Also added text about a study of the overall incidence of significant sequelae in patients with hemangiomas (cited Baselga et al. as reference 21).

Added Figure 2 depicting photos of different types of sequelae that occur after hemangioma involution.

Added text to state that there are many other published reports about the efficacy and safety of propranolol.

Added text about rebound growth after propranolol therapy, including the rebound rate and associated factors found in one multi-institutional, retrospective review of 997 patients with infantile hemangiomas (cited Shah et al. as reference 63).

Intermediate Tumors (Locally Aggressive)

Added text about the results of a multicenter, retrospective cohort study of 52 Chinese patients with progressive kaposiform hemangioendothelioma (cited Ji et al. as reference 22).

Intermediate Tumors (Rarely Metastasizing)

Added text about the results of a study of 56 Malawian children aged 3 to 12 years with Kaposi sarcoma who were treated with six courses of vincristine, bleomycin, and oral etoposide (cited Macken et al. as reference 25 and level of evidence 3iiA).

This summary is written and maintained by the PDQ Pediatric Treatment Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ® - NCI's Comprehensive Cancer Database pages.

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