domingo, 21 de febrero de 2016

Oncologists' and cancer patients' views on whole-exome sequencing and incidental findings: results from the CanSeq study. - PubMed - NCBI

Oncologists' and cancer patients' views on whole-exome sequencing and incidental findings: results from the CanSeq study. - PubMed - NCBI





 2016 Feb 11. doi: 10.1038/gim.2015.207. [Epub ahead of print]

Oncologists' and cancer patients' views on whole-exome sequencing and incidental findings: results from the CanSeq study.

Gray SW1,2,3Park ER4Najita J5Martins Y1Traeger L4Bair E1Gagne J1Garber J1,2,3Jänne PA1,2,3Lindeman N2,6Lowenstein C1Oliver N1Sholl L2,6Van Allen EM1,2,3,7Wagle N1,2,3,7Wood S1Garraway L1,2,3,7Joffe S8.

Abstract

PURPOSE:

Although targeted sequencing improves outcomes for many cancer patients, it remains uncertain how somatic and germ-line whole-exome sequencing (WES) will integrate into care.

METHODS:

We conducted surveys and interviews within a study of WES integration at an academic center to determine oncologists' attitudes about WES and to identify lung and colorectal cancer patients' preferences for learning WES findings.

RESULTS:

One-hundred sixty-seven patients (85% white, 58% female, mean age 60) and 27 oncologists (22% female) participated. Although oncologists had extensive experience ordering somatic tests (median 100/year), they had little experience ordering germ-line tests. Oncologists intended to disclose most WES results to patients but anticipated numerous challenges in using WES. Patients had moderately low levels of genetic knowledge (mean 4 correct out of 7). Most patients chose to learn results that could help select a clinical trial, pharmacogenetic and positive prognostic results, and results suggesting inherited predisposition to cancer and treatable noncancer conditions (all ≥95%). Fewer chose to receive negative prognostic results (84%) and results suggesting predisposition to untreatable noncancer conditions (85%).

CONCLUSION:

The majority of patients want most cancer-related and incidental WES results. Patients' low levels of genetic knowledge and oncologists' inexperience with large-scale sequencing present challenges to implementing paired WES in practice.Genet Med advance online publication 11 February 2016Genetics in Medicine (2016); doi:10.1038/gim.2015.207.

PMID:
 
26866579
 
[PubMed - as supplied by publisher]

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