Current Highlight from February 12, 2016
Effects of Salmonella and Norovirus Coinfection in an In Vitro Model
NCTR scientists demonstrated that simultaneous infection of an in vitro murine (mouse) macrophage cell model by Salmonella enterica serovar Heidelberg and murine norovirus resulted in a reduction in norovirus infection by 1) blocking viral entry, 2) an increase in Salmonella replication, and 3) a reduction in norovirus-induced cell death. This could result in prolonged infection by either Salmonella or norovirus, and could explain why some individuals sustain norovirus infection for months versus the normally observed two to three days. BothSalmonella and norovirus are foodborne pathogens that constitute a public-health threat and a major cause of gastrointestinal infections in the U.S. This study is available online at PLoS One
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For additional information, please contact Marli Azevedo, Ph.D., Division of Microbiology, FDA/NCTR.
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