Revised Table 7 to state that NCCN recommends that if an at-risk individual is found to not carry the APC gene mutation responsible for familial polyposis in the family, screening as an average-risk individual is recommended.
Revised Table 9 to state that NCCN recommends considering colectomy and ileorectal anastomosis in individuals aged 21 years or older with a personal history of MYH-associated polyposis and a small adenoma burden.
Revised text to state that NCCN supports immunohistochemistry or sometimes microsatellite instability testing of all CRCs diagnosed in patients younger than 70 years if tumor tissue is available and in patients 70 years or older if they meet Bethesda guidelines.
Revised Table 11 to state that NCCN recommends initiating CRC screening in MSH6 andPMS2 carriers between ages 25 years and 30 years or 2 to 5 years before the youngest case of CRC in the family if before age 30 years.
Revised Table 12 to state that NCCN does not recommend surveillance of the prostate in Lynch syndrome.
Revised text to state that an updated set of operational criteria for the diagnosis of Cowden syndrome based on a systematic literature review has been suggested and is currently utilized in the NCCN guidelines. Also added text to state that the American College of Medical Genetics and Genomics (ACMG) suggests that referral for genetics consultation be considered for individuals with a personal history of or a first-degree relative with 1) adult-onset Lhermitte-Duclos disease or 2) any three of the major or minor criteria that have been established for the diagnosis of Cowden syndrome; detailed recommendations, including diagnostic criteria for Cowden syndrome, can be found in the NCCN and ACMG guidelines.
ver historia personal en: www.cerasale.com.ar [dado de baja por la Cancillería Argentina por temas políticos, propio de la censura que rige en nuestro medio]//
weblog.maimonides.edu/farmacia/archives/UM_Informe_Autoevaluacion_FyB.pdf - //
weblog.maimonides.edu/farmacia/archives/0216_Admin_FarmEcon.pdf - //
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