Added text to state that POSTTEXT imaging grouping is performed after two and four cycles of chemotherapy to determine the optimal time for definitive surgery (cited Venkatramani et al. as reference 13).
Added text to state that the standard of care in the United States is preoperative chemotherapy when the tumor is unresectable and postoperative chemotherapy after complete resection, even if preoperative chemotherapy has already been given.
Added text to state that these tumors are treated differently than tumors of other stages and histologies.
Added text to state that in advanced tumors, surgical treatment of hepatoblastoma is a demanding procedure. Postoperative complications in high-risk patients decrease the rate of overall survival (cited Becker et al. as reference 36).
Added text to state that although the incidence of hepatocellular carcinoma in adults in the United States has steadily increased since the 1970s, possibly because of the increased frequency of chronic hepatitis C infection, the incidence in children has not increased.
Added text to state that a meta-analysis found seven randomized trials that compared resection alone versus transarterial chemoembolization (TACE) followed by resection. The 3-year event-free survival (EFS) and overall survival (OS) showed no difference between the two groups, but the 5-year EFS and OS favored TACE followed by resection (cited Yu et al. as reference 31).
ver historia personal en: www.cerasale.com.ar [dado de baja por la Cancillería Argentina por temas políticos, propio de la censura que rige en nuestro medio]//
weblog.maimonides.edu/farmacia/archives/UM_Informe_Autoevaluacion_FyB.pdf - //
weblog.maimonides.edu/farmacia/archives/0216_Admin_FarmEcon.pdf - //
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