Added text to state that outcomes for children with acute megakaryocytic leukemia (AMKL) vary between reported cooperative group trials, including the impact of t(1;22) on outcome. Also revised text to state that some studies have suggested that within the context of intensive chemotherapy and adequate supportive care, infants with t(1;22) can have a relatively favorable outcome that is superior to that of children with AMKL whose leukemia lacks t(1;22), with only 3 of 16 children with t(1;22) relapsing in two series; however, other studies have found the opposite in regard to outcome (cited Schweitzer et al. as reference 114).
Revised text about the CBFA2T3-GLIS2 fusion, including the incidence and outcome in acute myeloid leukemia (AML) patients.
Added text to state that in an Italian study of 47 pediatric chronic-phase CML patients treated with 340 mg/m2 per day of imatinib, complete cytogenetic response was achieved in 91.5% of patients at a median time of 6 months, and the rate of major molecular response at 12 months was 66.6%. Thus, it appears that starting with the higher dose of 340 mg/m2 has superior efficacy and is typically tolerable, with dose adjustment as needed for toxicity (cited Giona et al. as reference 29).
Revised text to state that the question of whether a pediatric patient with CML should receive an allogeneic transplant when multiple tyrosine kinase inhibitors are available remains unanswered; however, recent reports suggest that progression-free survival does not improve when utilizing hematopoietic stem cell transplantation, compared with the sustained use of imatinib.
ver historia personal en: www.cerasale.com.ar [dado de baja por la Cancillería Argentina por temas políticos, propio de la censura que rige en nuestro medio]//
weblog.maimonides.edu/farmacia/archives/UM_Informe_Autoevaluacion_FyB.pdf - //
weblog.maimonides.edu/farmacia/archives/0216_Admin_FarmEcon.pdf - //
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