Figure 1

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Object name is WJG-20-16649-g001.jpg

Humoral signals implicated in the physiological regulation of food intake. Diagram summarising the major signalling pathways which converge on the hypothalamus and brainstem in order to regulate food intake. ARC: Arcuate nucleus; NPY/AgRP: Neuropeptide Y and agouti-related peptide; POMC/CART: Proopiomelanocortin and cocaine- and amphetamine-regulated transcript; DVC: Dorsal vagal complex; DVN: Dorsal motor nucleus of vagus; NTS: Nucleus of the tractus solitarius; AP: Area postrema; GLP-1: Glucagon-like peptide-1; CCK: Cholecystokinin; PP: Pancreatic polypeptide; PYY: Peptide YY; OXM: Oxyntomodulin.

2014 Nov 28;20(44):16649-16664.

Could the improvement of obesity-related co-morbidities depend on modified gut hormones secretion?

Finelli C, Padula MC, Martelli G, Tarantino G.

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Abstract

Obesity and its associated diseases are a worldwide epidemic disease. Usual weight loss cures - as diets, physical activity, behavior therapy and pharmacotherapy - have been continuously implemented but still have relatively poor long-term success and mainly scarce adherence. Bariatric surgery is to date the most effective long term treatment for morbid obesity and it has been proven to reduce obesity-related co-morbidities, among them nonalcoholic fatty liver disease, and mortality. This article summarizes such variations in gut hormones following the current metabolic surgery procedures. The profile of gut hormonal changes after bariatric surgery represents a strategy for the individuation of the most performing surgical procedures to achieve clinical results. About this topic, experts suggest that the individuation of the crosslink among the gut hormones, microbiome, the obesity and the bariatric surgery could lead to new and more specific therapeutic interventions for severe obesity and its co-morbidities, also non surgical.