NIH Researchers Establish Human Model of H1N1 Flu Infection
In 2013, NIH researchers reported the initial results of a clinical study assessing H1N1 flu infection in healthy volunteers. The volunteers were infected with escalating doses of flu virus and monitored at the NIH Clinical Center.
The latest study reports how flu symptoms, virus levels, and immune responses correlate. The researchers established the optimal dose needed to induce mild-to-moderate illness and noted that symptoms appeared after viral shedding occurred, meaning that people may be infectious before flu symptoms develop.
The results of this study promises to improve the design of future flu research and clinical trials.