Drug-Resistant Candida glabrata Infection in Cancer Patients - Volume 20, Number 11—November 2014 - Emerging Infectious Disease journal - CDC
Volume 20, Number 11—November 2014
Drug-Resistant Candida glabrata Infection in Cancer Patients
Patients with cancer are often at risk for candidemia because of indwelling catheters, abdominal surgery, use of cytotoxic chemotherapy, parenteral nutrition, antibacterial drugs, and corticosteroids (1–5). Increasing drug resistance among Candida spp. poses an emerging threat to these patients. Moreover, the widespread prophylactic use of azoles in patients with hematologic malignancies and a reduced threshold for empiric initiation of antifungal treatment among critically ill patients have led to a notable shift from infections with C.albicans to infections with non-albicans Candida species (2–4). Among cancer patients, one of the most commonCandida species isolated is C. glabrata (3–5), which is the main species exhibiting multiazole, echinocandin, and multidrug resistance (resistance to at least 2 classes of antifungal drugs) (6–9).
Recently, on the basis of the integration of epidemiologic, molecular, and limited clinical data, the Clinical Laboratory Standards Institute (CLSI) updated antifungal susceptibility break points for Candida spp. (10,11). According to the new definitions, rates of caspofungin nonsusceptibility among C. glabrata clinical isolates range from <10% (12) to as high as 62% (13). Previous use of azoles or echinocandins are strong predictors of resistance to the respective classes (3,5,6,14,15), but little is known about the current rates of cross-resistance between azoles and echinocandins in patients with cancer or about additional clinical factors that could be associated with resistance. In a contemporary cohort of cancer patients with C. glabrata fungemia, we determined rates of in vitro resistance and cross-resistance to azoles and echinocandins, identified factors associated with resistance, and investigated the association between antifungal resistance and all-cause mortality rates.
Dr Farmakiotis is board certified in internal medicine and works as a transplant infectious diseases fellow at Brigham and Women’s Hospital and Dana Farber Cancer Institute. His research interests focus on fungal infections in immunocompromised patients with cancer, particularly those with hematologic malignancies.
We thank Dong Sik Yung for his contribution to data collection, Nathaniel D. Albert for technical support, and Ying Jang for her assistance with statistical analyses.
D.P.K. is the Frances King Black Endowed Professor for Cancer Research and. has received research support and honoraria from Astellas US, Pfizer, Gilead, and Merck & Co., Inc.
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Suggested citation for this article: Farmakiotis D, Tarrand JJ, Kontoyiannis DP. Drug-resistant Candida glabrata infection in cancer patients. Emerg Infect Dis [Internet]. 2014 Nov [date cited]. http://dx.doi.org/10.3201/eid2011.140685
1Current affiliation: Harvard Medical School Brigham and Women’s Hospital and Dana Farber Cancer Institute, Boston, Massachusetts, USA