Cystic Fibrosis: Progress in Outcomes 25 Years after Gene Discovery

Genomics|Update|Current

Cystic Fibrosis: Progress in Outcomes 25 Years after Gene Discovery

Cystic Fibrosis Foundation: CF is a life-threatening genetic disease that primarily affects the lungs and digestive system. An estimated 30,000 children and adults in the United States (70,000 worldwide) have CF

Identification of the cystic fibrosis gene: Chromosome walking and jumping. 
Rommens JM et al.  Science (1989)

Progress in treating cystic fibrosis means that many patients may now reach midlife and beyond
Bridget M. Kuehn, JAMA. 2014;312(12):1182-1183. 

Management of the upper airway in cystic fibrosis.
Illing EA, Woodworth BA. Curr Opin Pulm Med. 2014 Nov;20(6):623-31.

Adherence of subjects with cystic fibrosis to their home program: A systematic review. 
O'Donohoe R, Fullen BM. Respir Care. 2014 Jul 15

Improvements in lung function and height among cohorts of 6-year-olds with cystic fibrosis from 1994 to 2012. 
VanDevanter DR, et al.  J Pediatr. 2014 Aug 16

Self-management education for cystic fibrosis.
Savage E, Beirne PV, Ni Chroinin M, Duff A, Fitzgerald T, Farrell D. Cochrane Database Syst Rev. 2014 Sep 8;9:CD007641.

Cost-effectiveness of newborn screening for cystic fibrosis determined with real-life data. 
van der Ploeg CP, et al. J Cyst Fibros. 2014 Sep

Comprehensive CFTR gene analysis of the French cystic fibrosis screened newborn cohort: implications for diagnosis, genetic counseling, and mutation-specific therapy. 
Audrézet MP, et al. Genet Med. 2014 Aug 14.

Primary care providers' experiences notifying parents of cystic fibrosis newborn screening results. 
Finan C, et al.  Clin Pediatr (Phila). 2014 Aug 6

Disparities in current and future childhood and newborn carrier identification. 
Noke M, et al. J Genet Couns. 2014 Oct;23(5):701-7