The Integrative Human Microbiome Project: Dynamic Analysis of Microbiome-Host Omics Profiles during Periods of Human Health and Disease: Cell Host & Microbe
The Integrative Human Microbiome Project: Dynamic Analysis of Microbiome-Host Omics Profiles during Periods of Human Health and Disease
The human microbiome is important for human health, behavior, and disease, yet its function and dynamics during healthy and disease states are only partially understood. Studies of the microbiome to date have indicated impacts on personalized medicine ranging from inactivation of pharmaceuticals in some individuals (Haiser et al., 2013) to increased risk of cardiovascular disease due to microbial metabolic byproducts (Koeth et al., 2013). These findings show particular promise given that they have already come to light early in the field's transition from high-throughput discovery to detailed mechanistic studies, a process still ongoing after more than a decade of human omics. The first phase of the NIH Human Microbiome Project (HMP, fiscal years 2008–2012,http://www.commonfund.nih.gov/hmp) examined the diversity and composition of the human microbiome to evaluate (1) common patterns of microbial diversity associated with health and (2) whether taxonomic or functional features of the microbiome correlated with diseases by analyzing a large healthy cohort and a set of demonstration projects. These efforts revealed the vast microbial diversity associated with humans and provided new insights into the ecology of the host-microbiome supraorganism (Human Microbiome Project Consortium, 2012a,Human Microbiome Project Consortium, 2012b).