Alzheimer's Disease & Genetics: Recent Insights

Genomics|Update|Current

Alzheimer's Disease & Genetics: Recent Insights

CDC information: Facts about Alzheimer's disease

CDC report: 2013-2018 Road Map- The Healthy Brain Initiative

Did you know? 1615 genes have beern reported in relation to risk our outcomes of Alzheimer's disease, including 149 genomewide association studies? ApoE is the most commonly reported gene. To find out more, visit the HuGE Navigator

Find out what genetic conditions and tests are associated with Alzheimer’s disease, NIH Genetic Testing Registry

Recent Insights

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. 
Chia-Chen Liu et al.  Nature Reviews Neurology 9, 106-118 (February 2013)

Is apolipoprotein E required for cognitive function in humans?  Implications for Alzheimer drug development
Courtney Lane-Donovan et al. JAMA Neurology, August 11, 2014

Delete ApoE gene, set back Alzheimer’s, and preserve brain health? GEN News Highlights, Aug 12

Effects of the absence of apolipoprotein E on lipoproteins, neurocognitive function, and retinal function. 
Mak AC et al, JAMA Neurol. 2014 Aug 11. 

Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease. 
Katie Lunnon et al. Nature Neuroscience, August 18, 2014

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci. 
Philip L De Jager et al. Nature Neuroscience, August 18, 2014