martes, 8 de julio de 2014

NCTR Publications > NCTR Research Highlights

NCTR Publications > NCTR Research Highlights

National Center for Toxicological Researh log with FDA on left side

Current Highlight from July 4, 2014

Effect of Silver Nanoparticles on the Gut Microbes and Intestinal Immune Responses
NCTR scientists have shown that silver nanoparticles, administered by oral gavage, caused size- and dose-dependent changes in the gastrointestinal microbiota and the gut-associated immune response of rats; with smaller nanoparticles demonstrating the greatest antimicrobial capability.  Silver nanoparticles are widely used in the food and health care industry due to their antimicrobial properties; however, the effects of oral ingestion of nanosilver are largely unknown.  This study suggests that the microbiome may need to be considered in the safety evaluation of nanotechnology-derived products.  This would be added to traditional metabolism, toxicity, and tissue-deposition information currently used in toxicology risk assessments.  This study, which is part of a National Toxicology Program 13-week study, is currently published online at Nanotoxicologydisclaimer icon.
For additional information, please contact Sangeeta Khare, Ph.D., Division of Microbiology, FDA/NCTR.

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