lunes, 31 de marzo de 2014

Pretreatment selection of regimen according to ... [J Surg Oncol. 2014] - PubMed - NCBI

Pretreatment selection of regimen according to ... [J Surg Oncol. 2014] - PubMed - NCBI

 2014 Mar;109(3):250-4. doi: 10.1002/jso.23500. Epub 2013 Dec 7.

Pretreatment selection of regimen according to genetic analysis improves the efficacy of chemotherapy in the first line treatment of metastatic colorectal cancer.



Metastatic colon cancer patients are treated with the chemotherapy regimens, FOLFOX and FOLFIRI, in either order. So far, we cannot predict the response of chemotherapeutic agent, so it is necessary to find which regimen is adequate before starting chemotherapy.


Enrolled patients are randomized into either conventional treatment or planned treatment preceded by pretreatment genetic analysis. Blood samples of patients in planned treatment group (N = 53) were analyzed for the genetic polymorphism before selection of chemotherapeutic agents. Target genes were XPD-751, GSTP-1-105, XRCC1-399 for oxaliplatin, UGT1A1 for irinotecan. The response was measured by computed tomographic scan after completion of three cycles of chemotherapy.


Overall response rate was significantly higher in planned group (67.9% vs. 46.3%, P = 0.020). In FOLFOX group, response rate was significantly improved in the planned patients(77.1% vs. 50%, P = 0.018). In FOLFIRI group, the difference didn't reach statistical significance (50% vs. 42.5%, P = 0.776).


We found significantly improved response rates in the chemotherapy of metastatic colon cancer by pretreatment genetic analysis, especially in FOLFOX group.
© 2013 Wiley Periodicals, Inc.


genomic polymorphisms, metastatic colon cancer, pretreatment genetic analysis

[PubMed - indexed for MEDLINE]

No hay comentarios:

Publicar un comentario