lunes, 11 de noviembre de 2013

The Characteristics of Brea... [Appl Immunohistochem Mol Morphol. 2013] - PubMed - NCBI

The Characteristics of Brea... [Appl Immunohistochem Mol Morphol. 2013] - PubMed - NCBI

Appl Immunohistochem Mol Morphol. 2013 Oct 24. [Epub ahead of print]

The Characteristics of Breast Cancer Subtypes: Implications for Treatment Guidelines and Individualized Treatment Strategies in China.


Departments of *Pathology †Cancer Epidemiology **Center of Breast Disease, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing ‡Department of Oncosurgery, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an §Department of Breast Surgery, Zhejiang Cancer Hospital, Hangzhou ∥Department of Breast Oncology, Sun Yat-Sen University Cancer Center, Guangzhou ¶Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu, Sichuan #Department of Breast-thyroid Surgery, Xiangya Second Hospital, Central South University, Changsha, China.


This study aimed at investigating the characteristics of invasive breast cancer among molecular subtypes. Patients with invasive breast cancer, with complete information on the expressions of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2 (HER2), were recruited. χ tests and an unconditional logistic regression model were used for statistical analysis. The percentages of luminal A, luminal B, HER2/neu, and triple-negative subtypes were 54.2% (1639/3021), 14.0% (422/3021), 8.9% (269/3021), and 22.9% (691/3021), respectively. Differences among molecular subtypes (P<0 .05="" 2="" a="" adjusted="" age.="" age="" aggressive="" and="" b="" basis="" between="" both="" breast="" cancer="" china.="" compared="" conclusion="" differently="" distributed="" distribution="" findings="" for="" give="" groups="" guidelines="" her2="" in="" individualized="" invasive="" luminal="" lymph="" main="" may="" molecular="" more="" neu="" node="" observed.="" of="" on="" or="" p="" pathologic="" pathology="" regional="" size="" socioeconomic="" some="" stage="" status="" strategies="" subtype="" subtypes="" suggestions="" the="" treatment="" triple-negative="" tumor="" type="" updating="" variations="" were="" when="" with="">


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