domingo, 3 de noviembre de 2013

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease : Nature Genetics : Nature Publishing Group

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease : Nature Genetics : Nature Publishing Group

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

Journal name:
Nature Genetics
Year published:
DOI:
doi:10.1038/ng.2802
Received
Accepted
Published online
Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We conducted a large, two-stage meta-analysis of genome-wide association studies (GWAS) in individuals of European ancestry. In stage 1, we used genotyped and imputed data (7,055,881 SNPs) to perform meta-analysis on 4 previously published GWAS data sets consisting of 17,008 Alzheimer's disease cases and 37,154 controls. In stage 2, 11,632 SNPs were genotyped and tested for association in an independent set of 8,572 Alzheimer's disease cases and 11,312 controls. In addition to the APOE locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (P < 5 × 10−8) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer's disease.
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  1. Manhattan plot of stage 1 for genome-wide association with Alzheimer's disease (17,008 cases and 37,154 controls).
    Figure 1: Manhattan plot of stage 1 for genome-wide association with Alzheimer's disease (17,008 cases and 37,154 controls).
    The threshold for genome-wide significance (P < 5 × 10−8) is indicated by the red line. Genes previously identified by GWAS are shown in black, and newly associated genes are shown in red. Red diamonds represent SNPs with the smallest P values in the overall analysis.
  2. Regional plot for the PTK2B-CLU locus (17,008 cases and 37,154 controls).
    Figure 2: Regional plot for the PTK2B-CLU locus (17,008 cases and 37,154 controls).
right

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Author information

  1. These authors contributed equally to this work.

    • Jean-Charles Lambert,
    • Carla A Ibrahim-Verbaas,
    • Denise Harold,
    • Adam C Naj,
    • Sudha Seshadri,
    • Julie Williams,
    • Gerard D Schellenberg &
    • Philippe Amouyel

Affiliations

  1. INSERM, U744, Lille, France.

    • Jean-Charles Lambert,
    • Céline Bellenguez,
    • Benjamin Grenier-Boley,
    • Vincent Chouraki,
    • Nathalie Fiévet &
    • Philippe Amouyel

  2. Université Lille 2, Lille, France.

    • Jean-Charles Lambert,
    • Céline Bellenguez,
    • Benjamin Grenier-Boley,
    • Vincent Chouraki,
    • Florence Pasquier,
    • Vincent Deramecourt &
    • Philippe Amouyel

  3. Institut Pasteur de Lille, Lille, France.

    • Jean-Charles Lambert,
    • Céline Bellenguez,
    • Benjamin Grenier-Boley,
    • Vincent Chouraki,
    • Nathalie Fiévet &
    • Philippe Amouyel

  4. Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

    • Carla A Ibrahim-Verbaas,
    • M Arfan Ikram &
    • Renee F A G de Bruijn

  5. Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

    • Carla A Ibrahim-Verbaas,
    • M Arfan Ikram,
    • Najaf Amin,
    • Renee F A G de Bruijn,
    • Albert Hofman &
    • Cornelia M van Duijn

  6. Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK.

    • Denise Harold,
    • Rebecca Sims,
    • Nicola Jones,
    • Charlene Thomas,
    • Amy Gerrish,
    • Melanie L Dunstan,
    • Paul Hollingworth,
    • Michael J Owen,
    • Michael C O'Donovan,
    • Lesley Jones,
    • Peter A Holmans,
    • Valentina Moskvina &
    • Julie Williams

  7. Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

    • Adam C Naj

  8. Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

    • Adam C Naj

  9. Department of Medicine (Biomedical Genetics), Boston University School of Public Health, Boston, Massachusetts, USA.

    • Gyungah Jun,
    • Badri N Vardarajan,
    • Clinton Baldwin &
    • Lindsay A Farrer

  10. Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, USA.

    • Gyungah Jun &
    • Lindsay A Farrer

  11. Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.

    • Gyungah Jun,
    • Anita L DeStefano,
    • Seung-Hoan Choi,
    • Kathryn L Lunetta &
    • Lindsay A Farrer

  12. Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.

    • Joshua C Bis,
    • Annette L Fitzpatrick,
    • Tamara B Harris &
    • Bruce M Psaty

  13. John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.

    • Gary W Beecham,
    • Brian Kunkle,
    • John R Gilbert,
    • Kara L Hamilton-Nelson,
    • Eden R Martin &
    • Margaret A Pericak-Vance

  14. Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, USA.

    • Gary W Beecham,
    • John R Gilbert,
    • Eden R Martin &
    • Margaret A Pericak-Vance

  15. Functional Genomics Center Zurich, Eidgenössische Technische Hochschule (ETH)/University of Zurich, Zurich, Switzerland.

    • Giancarlo Russo

  16. Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.

    • Tricia A Thornton-Wells &
    • Jonathan L Haines

  17. Faculty of Medicine, University of Iceland, Reykjavik, Iceland.

    • Albert V Smith,
    • Vilmundur Gudnason &
    • Palmi V Jonsson

  18. Icelandic Heart Association, Kopavogur, Iceland.

    • Albert V Smith,
    • Vilmundur Gudnason &
    • Gudny Eiriksdottir

  19. Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

    • M Arfan Ikram

  20. Netherlands Consortium for Healthy Aging, Leiden, The Netherlands.

    • M Arfan Ikram,
    • Renee F A G de Bruijn,
    • Albert Hofman &
    • Cornelia M van Duijn

  21. Centre National de Génotypage, Institut Génomique, Commissariat à l'Energie Atomique, Evry, France.

    • Diana Zelenika,
    • Marie-Thérèse Bihoreau &
    • Mark Lathrop

  22. Fondation Jean Dausset, Centre d'Etude du Polymorphisme Humain (CEPH), Paris, France.

    • Yoichiro Kamatani &
    • Mark Lathrop

  23. Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

    • Chiao-Feng Lin,
    • Otto Valladares,
    • Laura B Cantwell,
    • Li-San Wang &
    • Gerard D Schellenberg

  24. Institute for Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.

    • Helena Schmidt

  25. Memory Clinic of Fundació Alzheimer Centre Educacional (ACE). Institut Català de Neurociències Aplicades, Barcelona, Spain.

    • Agustin Ruiz &
    • Mercè Boada

  26. Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA.

    • Christiane Reitz &
    • Richard Mayeux

  27. Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, USA.

    • Christiane Reitz &
    • Richard Mayeux

  28. Centre National de Reference pour les Malades Alzheimer Jeunes (CNR-MAJ), Centre Hospitalier Régional Universitaire de Lille, Lille, France.

    • Florence Pasquier,
    • Vincent Deramecourt &
    • Philippe Amouyel

  29. Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.

    • Alfredo Ramirez &
    • Wolfgang Maier

  30. Institute of Human Genetics, University of Bonn, Bonn, Germany.

    • Alfredo Ramirez

  31. University Paris Descartes, Sorbonne Paris V, Broca Hospital, Geriatrics Department, Paris, France.

    • Olivier Hanon

  32. Department of Epidemiology, University of Washington, Seattle, Washington, USA.

    • Annette L Fitzpatrick,
    • Walter A Kukull &
    • Bruce M Psaty

  33. Department of Global Health, University of Washington, Seattle, Washington, USA.

    • Annette L Fitzpatrick

  34. Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA.

    • Joseph D Buxbaum

  35. Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA.

    • Joseph D Buxbaum

  36. Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, USA.

    • Joseph D Buxbaum

  37. CNR-MAJ, INSERM, U1079, Rouen University Hospital, Rouen, France.

    • Dominique Campion,
    • David Wallon &
    • Didier Hannequin

  38. Department of Medicine, University of Washington, Seattle, Washington, USA.

    • Paul K Crane &
    • Eric B Larson

  39. German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.

    • Tim Becker &
    • Wolfgang Maier

  40. Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany.

    • Tim Becker

  41. Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.

    • Carlos Cruchaga &
    • Alison M Goate

  42. Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, USA.

    • Carlos Cruchaga &
    • Alison M Goate

  43. Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK.

    • David Craig,
    • Janet A Johnston,
    • Bernadette McGuinness,
    • Stephen Todd &
    • Peter Passmore

  44. INSERM, U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier, France.

    • Claudine Berr &
    • Karen Ritchie

  45. Departments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

    • Oscar L Lopez

  46. Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

    • Philip L De Jager

  47. Program in Medical and Population Genetics, Broad Institute, Boston, Massachusetts, USA.

    • Philip L De Jager

  48. Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA.

    • Denis Evans

  49. Institute of Psychiatry, King's College London, Denmark Hill, London, UK.

    • Simon Lovestone,
    • Petroula Proitsi &
    • John F Powell

  50. INSERM, U897, Victor Segalen University, Bordeaux, France.

    • Luc Letenneur,
    • Pascale Barberger-Gateau,
    • Carole Dufouil &
    • Jean-François Dartigues

  51. Departamento de Genómica Estructural, Neocodex, Seville, Spain.

    • Francisco J Morón

  52. Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.

    • David C Rubinsztein &
    • Peter St George-Hyslop

  53. Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium.

    • Kristel Sleegers,
    • Karolien Bettens &
    • Christine Van Broeckhoven

  54. Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.

    • Kristel Sleegers,
    • Karolien Bettens &
    • Christine Van Broeckhoven

  55. Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA.

    • Matthew J Huentelman

  56. Mercer's Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland.

    • Michael Gill

  57. Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK.

    • Kristelle Brown &
    • Kevin Morgan

  58. Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

    • M Ilyas Kamboh

  59. Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

    • M Ilyas Kamboh

  60. Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.

    • Lina Keller &
    • Laura Fratiglioni

  61. Group Health Research Institute, Group Health, Seattle, Washington, USA.

    • Eric B Larson &
    • Bruce M Psaty

  62. Department of Medicine and Partners Center for Personalized Genetic Medicine, Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

    • Robert Green

  63. Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, USA.

    • Amanda J Myers

  64. University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol, UK.

    • Seth Love

  65. Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada.

    • Ekaterina Rogaeva &
    • Peter St George-Hyslop

  66. Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, UK.

    • John Gallacher &
    • Anthony Bayer

  67. Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

    • Peter St George-Hyslop

  68. Neurology Department. Biomedical Research Institute Sant Pau (IIB Sant Pau). Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona, Spain.

    • Jordi Clarimon &
    • Alberto Lleo

  69. Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain.

    • Jordi Clarimon &
    • Alberto Lleo

  70. Geriatric Research, Education and Clinical Center (GRECC), Veteran Administration Puget Sound Health Care System (VAPSHCS), Seattle, Washington, USA.

    • Debby W Tsuang

  71. Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.

    • Lei Yu &
    • David A Bennett

  72. Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece.

    • Magda Tsolaki

  73. Clinical and Behavioral Neurology, Fondazione Santa Lucia, Rome, Italy.

    • Paola Bossù &
    • Gianfranco Spalletta

  74. MRC Prion Unit, Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK.

    • John Collinge &
    • Simon Mead

  75. NEUROFARBA (Department of Neuroscience, Psychology, Drug Research and Child Health), University of Florence, Florence, Italy.

    • Sandro Sorbi &
    • Benedetta Nacmias

  76. Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy.

    • Sandro Sorbi &
    • Benedetta Nacmias

  77. Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain.

    • Florentino Sanchez-Garcia &
    • Maria Candida Deniz Naranjo

  78. Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK.

    • Nick C Fox

  79. Department of Molecular Neuroscience, Institute of Neurology, London, UK.

    • John Hardy

  80. Reta Lilla Weston Laboratories, Institute of Neurology, London, UK.

    • John Hardy

  81. Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Associazione Oasi Maria Santissima Srl, Troina, Italy.

    • Paolo Bosco

  82. Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford, UK.

    • Robert Clarke

  83. Institute of Public Health, University of Cambridge, Cambridge, UK.

    • Carol Brayne

  84. University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy.

    • Daniela Galimberti

  85. Neurological Clinic, University of Pisa, Pisa, Italy.

    • Michelangelo Mancuso

  86. MRC Biostatistics Unit, Cambridge, UK.

    • Fiona Matthews

  87. Urban Epidemiology, Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.

    • Susanne Moebus

  88. Section of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy.

    • Patrizia Mecocci

  89. Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.

    • Maria Del Zompo

  90. Department of Psychiatry, University of Frankfurt, Frankfurt am Main, Germany.

    • Harald Hampel

  91. Department of Psychiatry, Ludwig Maximilians University, Munich, Germany.

    • Harald Hampel

  92. Gerontology and Geriatrics Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.

    • Alberto Pilotto

  93. Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas–Universidad Autónoma de Madrid, Madrid, Spain.

    • Maria Bullido

  94. Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.

    • Maria Bullido

  95. Instituto de Investigación Sanitaria Hospital la Paz (IdIPaz), Madrid, Spain.

    • Maria Bullido

  96. Departement of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy.

    • Francesco Panza

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    • Paolo Caffarra

  98. Center for Cognitive Disorders, Azienda Unita Sanitaria Local (AUSL), Parma, Italy.

    • Paolo Caffarra

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    • Cristina Razquin &
    • Pau Pastor

  106. CIBERNED, Instituto de Salud Carlos III, Madrid, Spain.

    • Pau Pastor

  107. Neurology Service, Marqués de Valdecilla University Hospital, University of Cantabria and Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain.

    • Ignacio Mateo &
    • Onofre Combarros

  108. CIBERNED, Marqués de Valdecilla University Hospital, University of Cantabria and IFIMAV, Santander, Spain.

    • Ignacio Mateo &
    • Onofre Combarros

  109. Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA.

    • Kelley M Faber &
    • Tatiana M Foroud

  110. Geriatric Department, Landspitali University Hospital, Reykjavik, Iceland.

    • Palmi V Jonsson

  111. Institute of Clinical Medicine–Neurology, University of Eastern Finland, Kuopio, Finland.

    • Hilkka Soininen &
    • Mikko Hiltunen

  112. Department of Neurology, Kuopio University Hospital, Kuopio, Finland.

    • Hilkka Soininen &
    • Mikko Hiltunen

  113. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.

    • Deborah Blacker

  114. Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA.

    • Deborah Blacker

  115. Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, Mississippi, USA.

    • Thomas H Mosley Jr

  116. Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.

    • David A Bennett &
    • Caroline Graff

  117. Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden.

    • Laura Fratiglioni

  118. Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK.

    • Clive Holmes

  119. Department of Pathology, University of Washington, Seattle, Washington, USA.

    • Thomas J Montine

  120. Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

    • Jerome I Rotter

  121. INSERM UMRS 975, CNRS UMR 7225, Université Pierre et Marie Curie, Centre de Recherche de l'Institut du Cerveau et de la Moëlle Epinière (CRICM), Hôpital de la Salpêtrière, Paris, France.

    • Alexis Brice

  122. Assistance Publique des Hôpitaux de Paris (AP-HP), Hôpital de la Pitié–Salpêtrière, Paris, France.

    • Alexis Brice

  123. Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, USA.

    • Michael A Nalls

  124. Faculty of Medicine, Imperial College, St. Mary's Hospital, London, UK.

    • Karen Ritchie

  125. Department of Biology, Brigham Young University, Provo, Utah, USA.

    • John S K Kauwe

  126. Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA.

    • Eric Boerwinkle

  127. Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA.

    • Eric Boerwinkle

  128. Division of Epidemiology, University of Texas Health Sciences Center at Houston, Houston, Texas, USA.

    • Eric Boerwinkle

  129. Hospital Universitari Vall d'Hebron–Institut de Recerca, Universitat Autònoma de Barcelona. (VHIR-UAB), Barcelona, Spain.

    • Mercè Boada

  130. Department of Neurology, Medical University of Graz, Graz, Austria.

    • Reinhold Schmidt

  131. Department of Psychiatry, University of Halle, Halle, Germany.

    • Dan Rujescu

  132. Centre de Mémoire de Ressources et de Recherche de Bordeaux, Centre Hospitalier Universitaire (CHU) de Bordeaux, Bordeaux, France.

    • Jean-François Dartigues

  133. INSERM, U708, Victor Segalen University, Bordeaux, France.

    • Christophe Tzourio

  134. Institute of Human Genetics, Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.

    • Markus M Nöthen

  135. Department of Neurobiology, Karolinska Institutet, Care Sciences and Society, Karolinska Institute–Alzheimer's Disease Research Center (KIADRC), Stockholm, Sweden.

    • Caroline Graff

  136. Department of Health Service, University of Washington, Seattle, Washington, USA.

    • Bruce M Psaty

  137. Vanderbilt Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, USA.

    • Jonathan L Haines

  138. McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada.

    • Mark Lathrop

  139. Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, USA.

    • Lenore J Launer

  140. Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.

    • Lindsay A Farrer

  141. Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.

    • Lindsay A Farrer &
    • Sudha Seshadri

  142. Center for Medical Systems Biology, Leiden, The Netherlands.

    • Cornelia M van Duijn

  143. Centre Hospitalier Régional Universitaire de Lille, Lille, France.

    • Philippe Amouyel

  144. These authors jointly directed this work.

    • Sudha Seshadri,
    • Julie Williams,
    • Gerard D Schellenberg &
    • Philippe Amouyel

Consortia

  1. European Alzheimer's Disease Initiative (EADI)

  2. Full lists of members and affiliations appear in the Supplementary Note

  3. Genetic and Environmental Risk in Alzheimer's Disease (GERAD)

  4. Full lists of members and affiliations appear in the Supplementary Note

  5. Alzheimer's Disease Genetic Consortium (ADGC)

  6. Full lists of members and affiliations appear in the Supplementary Note

  7. Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE)

  8. Full lists of members and affiliations appear in the Supplementary Note

Contributions

Study concept and design: J.-C.L., C.A.I.-V., D. Harold, A.C.N., A.L.D., J.C.B., A.V.S., M.A.I., H. Schmidt, A.L.F., V.G., O.L.L., D.W.T., D. Blacker, T.H.M., T.B.H., J.I.R., W.A.K., M. Boada, R. Schmidt, R.M., A.H., B.M.P., J.L.H., P.A.H., M.L., M.A.P.-V., L.J.L., L.A.F., C.M.v.D., V.M., S. Seshadri, J.W., G.D.S. and P.A. Acquisition of data: J.-C.L., C.A.I.-V., D. Harold, C. Bellenguez, R. Sims, G.J., B.G.-B., G.R., N.J., V.C., C. Thomas, D.Z., Y.K., A.G., H. Schmidt, M.L.D., M.-T.B., S.-H.C., P.H., V.G., C. Baldwin, C.C., C. Berr, O.L.L., P.L.D.J., D.E., L. Letenneur, G.E., K.S., A.M.G., N.F., M.J.H., M.I.K., E.B.L., A.J.M., C.D., S.T., S. Love, E.R., P.S.G.-H., L.Y., M.M.C., D. Beekly, F.Z., O.V., S.G.Y., W.G., M.J.O., K.M.F., P.V.J., M.C.O., L.B.C., D.A.B., T.B.H., R.F.A.G.d.B., T.J.M., J.I.R., K.M., T.M.F., W.A.K., J.F.P., M.A.N., K.R., J.S.K.K., E.B., M.R., M. Boada, L.-S.W., J.-F.D., C. Tzourio, M.M.N., B.M.P., L.J., J.L.H., M.L., L.J.L., L.A.F., A.H., C.M.v.D., S. Seshadri, J.W., G.D.S. and P.A. Sample contribution: A. Ruiz, F. Pasquier, A. Ramirez, O.H., J.D.B., D. Campion, P.K.C., C. Baldwin, T.B., C.C., D. Craig, V.D., J.A.J., S. Lovestone, F.J.M., D.C.R., K.S., A.M.G., N.F., M.G., K. Brown, M.I.K., L.K., P.B.-G., B.M., R.G., A.J.M., D.W., E.R., J.G., P.S.G.-H., J.C., A.L., A. Bayer, M.T., P. Bossù, G.S., P. Proitsi, J.C., S. Sorbi, F.S.-G., N.C.F., J.H., M.C.D.N., P. Bosco, R.C., C. Brayne, D.G., M. Mancuso, F.M., S. Moebus, P.M., M.D.Z., W.M., H. Hampel, A.P., M. Bullido, F. Panza, P.C., B.N., M. Mayhaus, L. Lannfelt, H. Hakonarson, S.P., M.M.C., M.I., V.A., S.G.Y., E.C., C. Razquin, P. Pastor, I.M., O.C., H. Soininen, S. Mead, D.A.B., L.F., C.H., P. Passmore, T.J.M., K. Bettens, A. Brice, D. Hannequin, K.R., M.R., M.H., D.R., C.G. and C.V.B. Data analysis: C.A.I.-V., D. Harold, A.C.N., R. Sims, C. Bellenguez, G.J., A.L.D., J.C.B., G.W.B., B.G.-B., G.R., T.A.T.-W., N.J., A.V.S., V.C., M.A.I., D.Z., Y.K., B.N.V., C.-F.L., A.G., B.K., C. Reitz, J.R.G., O.V., W.A.K., K.L.L., K.L.H.-N., E.R.M., L.-S.W., B.M.P., M.L., V.M. and J.W. Statistical analysis and interpretation: J.-C.L., C.A.I.-V., D. Harold, A.C.N., C. Bellenguez, G.J., A.L.D., J.C.B., G.W.B., T.A.T.-W., A.V.S., V.C., M.A.I., B.N.V., Y.K., C.-F.L., B.K., C. Reitz, A.L.F., N.A., J.R.G., R.F.A.G.d.B., W.A.K., K.L.L., E.R.M., L.-S.W., B.M.P., L.J., J.L.H., P.A.H., M.A.P.-V., L.J.L., L.A.F., C.M.v.D., V.M., S. Seshadri, J.W., G.D.S. and P.A. Drafting of the manuscript: J.-C.L., C.A.I.-V., D. Harold, A.C.N., C. Bellenguez, A.L.D., J.C.B., A.V.S., R.M., B.M.P., J.L.H., M.A.P.-V., L.J.L., L.A.F., C.M.v.D., C.V.B., S. Seshadri, J.W., G.D.S. and P.A.

Competing financial interests

The authors declare no competing financial interests.

Corresponding authors

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Author details

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  1. Supplementary Text and Figures (3,270 KB)
    Supplementary Figures 1–18, Supplementary Tables 1–10 and Supplementary Note

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