Reviews & Commentaries on Science & Technology
Telltale hearts. Each year, tens of thousands of young people worldwide die suddenly after their hearts stop beating for no apparent reason. Genetic testing for inherited heart rhythm disorders AKA 'molecular autopsies' are rarely performed.Jeanne Erdmann. Nature Medicine, Nov 8
Extensive variation in chromatin states across humans
Maya Kasowski et al, Science, Nov 8
Genetics driving epigenetics.
Terrence S. Furey et al. Science, Nov 8
Genome-wide consequences of deleting any single gene
Teng X, et al. Molecular Cell, 2013 Nov 7
The vicious cycle of under-valued cancer biomarkers. Could sweeping changes bring more tests into clinical practice?
Genna Rollins, American Association for Clinical Chemistry, Nov 2013
Blog post: One person, many genomes,
First director named for NHGRI's new Division of Genomics and Society,
NextCODE Health Mines deCODE's data, and more, to catalyze clinical diagnosis,
When causal disease alleles don't cause disease (or is that the norm?)
Can genomics blow up the clinical trial?
How much bioinformatics does the new biologist need?
Weak statistical standards implicated in scientific irreproducibility- One-quarter of studies that meet commonly used statistical cutoff may be false.
Documentary: Exosomes – the next small thing,
Receptive to replication: Do replication studies belong in top-tier journals?
Heterogeneity in cancer genomics,
Practicing precision medicine in cancer using genomics - Louis Staudt,
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