A century after Fisher: time for a new paradigm in quantitative genetics

Available online 23 October 2013

In Press, Corrected Proof — Note to users

Opinion

A century after Fisher: time for a new paradigm in quantitative genetics

• Ronald M. Nelson ,
• Mats E. Pettersson,
• Örjan Carlborg

• Swedish University of Agricultural Sciences, Department of Clinical Sciences, Division of Computational Genetics, Box 7078, SE-750 07 Uppsala, Sweden

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Highlights

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We present a challenge to the Fisherian quantitative genetics paradigm.

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The natural state of biological systems cannot be fully captured with an additive model.

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We urge researchers to design experiments that can detect nonadditive genetic interactions.

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It is important to keep an open mind when selecting an analysis method.