Breast Milk Supply May Be Linked to Insulin Production: Study
Findings could have implications for prediabetic mothers, researchers say
Sunday, July 7, 2013
The researchers describe how milk-producing glands become highly sensitive to insulin during lactation and how specific genes in the glands are switched on during lactation.
RNA sequencing technology revealed "in exquisite detail" the blueprint for milk production in the mammary glands, said study corresponding author Laurie Nommsen-Rivers, a scientist at Cincinnati Children's Hospital Medical Center.
The findings are published online July 5 in the journal PLoS One.
"This new study shows a dramatic switching on of the insulin receptor and its downstream signals during the breast's transition to a biofactory that manufactures massive amounts of proteins, fats and carbohydrates for nourishing the newborn baby," Nommsen-Rivers said in a medical center news release.
In previous research, Nommsen-Rivers found that new mothers with characteristics linked to poor glucose metabolism -- such as being overweight, older or having a large baby -- take longer to begin producing milk. This suggested that insulin was a factor in milk production.
"Considering that 20 percent of women between 20 and 44 are prediabetic, it's conceivable that up to 20 percent of new mothers in the United States are at risk for low milk supply due to insulin dysregulation," she added.
Nommsen-Rivers and her colleagues are planning a study to determine if a drug used to control blood sugar in people with type 2 diabetes boosts insulin action in mammary glands and improves milk supply.
"The ideal approach is a preventive one," she said. "Modifications in diet and exercise are more powerful than any drug. After this clinical trial, we hope to study those interventions."
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