NCTR Research Highlights
Current Highlight from October 12, 2012
NCTR scientists contributed a chapter describing Campylobacter jejuni to the second edition of FDA’s "Foodborne Pathogenic Microorganisms and Natural Toxins Handbook," also known as "Bad Bug Book," published by the Center for Food Safety and Applied Nutrition (Bad Bug Book, 2012, 2nd Edition: 17-20). C. jejuni is the most frequently identified etiological agent from food samples in human cases of Campylobacter-associated gastroenteritis, which can last from two to ten days. Major sources of C. jejuni are raw poultry, unpasteurized milk and cheeses, and contaminated water. The Bad Bug Book is a handbook that provides scientific and technical information in plain language about pathogens and toxins that contaminate foods.
For additional information, please contact Rajesh Nayak, Ph.D., Division of Microbiology, FDA/NCTR.
Carcinogenic Activity of Aloe Vera Whole Leaf Extract
NCTR scientists have shown that Aloe vera whole-leaf extract administered to rats in drinking water in a two-year carcinogenicity bioassay was an intestinal irritant and had clear carcinogenic activity in the colon. Aloe vera is a widely used herbal remedy used for the treatment of constipation, detoxification, and as a prophylaxis. This study was supported through the Interagency Agreement with the National Toxicology Program. A manuscript describing this study was recently accepted for publication in Toxicological Sciences.
For additional information, please contact Mary Boudreau, Ph.D., Division of Biochemical Toxicology, FDA/NCTR, or Frederick Beland, Ph.D., Director, Division of Biochemical Toxicology, FDA/NCTR.
Development Effects and Pregnancy Outcomes Associated with Cancer Chemotherapy Use During Pregnancy
The National Toxicology Program (NTP) at the National Institute of Environmental Health Sciences held a public meeting on October 1-2, 2012, on the NIEHS campus to review the monograph "Development Effects and Pregnancy Outcomes Associated with Cancer Chemotherapy Use During Pregnancy." The peer-review panel included nine subject-matter experts and representatives from the FDA and National Institute for Occupational Safety and Health, and the content of the draft monograph was reviewed for accuracy of the content. This publically reviewed document will be further reviewed for content at the next meeting of the NTP Board of Scientific Counselors.
For additional information, please contact Paul Howard, Ph.D., Director, Office of Scientific Coordination, FDA/NCTR.