High-throughput screen identifies non inflammatory small molecule inducers of trained immunity

https://www.pnas.org/doi/10.1073/pnas.2400413121?utm_campaign=+61510452&utm_content=&utm_medium=email&utm_source=govdelivery&utm_term= NIAID-supported scientists have identified small molecules that trigger trained immunity, a form of innate immune-system memory, without a pathogen or host molecule activating innate immunity first. These newly identified compounds surprisingly include steroids, which are usually immunosuppressive. Also, unlike the few previously identified molecules that trigger trained immunity, the new ones are easy to make and deliver, the scientists say. These findings could help researchers develop new or improved vaccines and treatments.