Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer M Wong et al, Nature Medicine, October 5, 2020

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 Childhood Cancer

Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer
M Wong et al, Nature Medicine, October 5, 2020

The Zero Childhood Cancer Program is a precision medicine program to benefit children with poor-outcome, rare, relapsed or refractory cancer. Using tumor and germline whole genome sequencing (WGS) and RNA sequencing (RNAseq) across 252 tumors from high-risk pediatric patients with cancer, we identified 968 reportable molecular aberrations.