When antibodies mislead: the quest for validation

When antibodies mislead: the quest for validation

When research antibodies mislead

Commercial antibodies are commonplace in biology laboratories. Researchers use these giant Y-shaped proteins to detect specific molecules in cells, tissues and test tubes. But sometimes the proteins detect other molecules, too — or even instead. Scientists are seeking ways to ensure that research antibodies can be validated and identified to ensure that antibody-driven experiments are trustworthy and reproducible.

Nature | 7 min read