domingo, 26 de julio de 2020

Molecular Underpinnings of Severe Coronavirus Disease 2019 RM Plenge, JAMA, July 24, 2020

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Coronavirus
In 4 young male patients with severe COVID-19 from 2 families, rare loss-of-function variants of the X-chromosomal TLR7 were identified, with immunological defects in type I and II interferon production. These findings provide insights into the pathogenesis of COVID-19.
The median model-based estimate of the prevalence of any of five underlying medical conditions associated with increased risk for severe COVID-19–associated illness among U.S. adults was 47.2% among 3,142 U.S. counties. The estimated number of persons with these conditions followed population distributions, but prevalence was higher in more rural counties.
Mathematical models to guide pandemic response
CJE Metcalf et al, Science, July 23, 2020
Despite the devastating burden that COVID-19 has imposed so far, most of the world is still susceptible to SARS-CoV-2 infection. Models projecting into this future have evaluated policy scenarios and assessed the potential impact of seasonal variation in transmission.
The role of chest radiography in confirming covid-19 pneumonia.
Cleverley Joanne et al. BMJ (Clinical research ed.) 2020 07 m2426
A normal chest radiograph does not exclude covid-19 pneumonia. No single feature of covid-19 pneumonia on a chest radiograph is specific or diagnostic, but a combination of multifocal peripheral lung changes of ground glass opacity and/or consolidation, which are most commonly bilateral, may be present.

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