CIENCIASMEDICASNEWS: Medical News | Medical Articles: Thermal Analysis Assures the Quality of Pharmaceuticals

jueves, 3 de octubre de 2019

Medical News | Medical Articles: Thermal Analysis Assures the Quality of Pharmaceuticals

	October 3, 2019
	Drug Discovery and Production
	The latest drug discovery news from News Medical

Thermal Analysis Assures the Quality of Pharmaceuticals

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How to Monitor Phase Transitions in Pharmaceuticals

Polymorphism in pharmaceutical solids is the ability of a substance to exist in more than one molecular arrangement, resulting in numerous polymorphic forms which differ in their physiochemical properties such as solubility, melting point, stability, etc. It has a big impact on both the performance and processing of solid pharmaceutical products.

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	New antibiotics on the horizon as scientists discover a weakness in the cell wall of pathogenic bacteria Researchers have discovered a weak spot in the cell wall of pathogenic bacteria that could lead to the development of new antibiotics. This was a joint collaboration between researchers at the Hokkaido University of Japan, Duke University in the US and The Catholic University of Korea.

	New mechanism that controls DNA repair identified Deoxyribonucleic acid (DNA), is the macromolecule that holds all hereditary and genetic information. Continuously under assault, alterations and damage to DNA can lead to many different health issues, including cancer. DNA is highly regulated within cells, where multiple mechanisms are at play to repair and protect its integrity. Scientists are still investigating these mechanisms to fully comprehend how these DNA repair processes are managed.

	Importance of Solubility and Lipophilicity in Drug Development Solubility and lipophilicity are basic physicochemical properties, but also key parameters that can dictate the success or failure rate of drug discovery and development. In short, their measurement is pivotal for both in vitro and in silico evaluation of drug properties.

	Using AI to transform drug discovery in a big way According to the National Cancer Institute, approximately 38 percent of men and women will be diagnosed with cancer at some point in their lives. The current process for drug discovery is slow and sequential, and often involves high failure rates for drug candidates. Can artificial intelligence (AI) be used to transform the existing drug discovery process into a rapid, integrated, and patient-centric model?

	Exploring the Structure-Activity Relationship (SAR) of Drugs The structure-activity relationship (SAR) aids in understanding various aspects of drug discovery, from screening drug candidates to optimizing their properties. The effective biological activity is contributed by the various geometric and electrostatic interactions.

	'A new era of drug discovery’: Company develops drug using AI For the first time, a Toronto-based company called Deep Genomics has discovered a drug target and corresponding candidate using artificial intelligence (AI). The company announced yesterday that its AI-based drug discovery platform has identified a new treatment target and drug candidate for Wilson disease, a potentially life-threatening genetic disorder.