CIENCIASMEDICASNEWS: Medical News | Medical Articles: Fragment-Based Drug Discovery: Case Histories and Combining Orthogonal Methods

martes, 20 de agosto de 2019

Medical News | Medical Articles: Fragment-Based Drug Discovery: Case Histories and Combining Orthogonal Methods

	August 20, 2019
	Biochemistry
	The latest biochemistry news from AZoNetwork

Fragment-Based Drug Discovery: Case Histories and Combining Orthogonal Methods

FBDD is now a key starting point for the discovery of high-quality preclinical candidates. In this webinar, Dr. Ben Davis and Dr. Matteo Pennestri discuss real cases from the pharmaceutical industry and the use of NMR-guided models to progress fragments when X-ray crystal structures are not available.

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Flexible Methods for Long-Read RNA Sequencing

RNA analysis has become a vital tool for researchers looking for insight into the study of living things, revealing details about the dynamics of the transcriptome, from single cells to whole tissues. When applied to medicine, the identification of differentially spliced isoforms and fusion transcripts can assist doctors in providing disease diagnosis and treatment.

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Spin Labels in Electron Spin Resonance (ESR) Spectroscopy

In ESR, a spin label is added to the target site using cysteine substitution. This is followed by modifying the sulfhydryl group with a paramagnetic nitroxide reagent. The ESR then provides information about the mobility of nitroxide side chain, accessibility of the solvent, distance between nitroxide and other paramagnetic centers.

	2D NMR Spectroscopy: Fundamentals, Methods and Applications 2D NMR differs from 1D NMR by the acquisition stage being separated from the excitation stage. The stages in between these are called evolution and mixing. The evolution sequence lets nuclei precess freely, during which time the magnetization is labeled. The mixing sequence sees this magnetization transferred to another nucleus. Lastly, during detection, the magnetization is labeled by a chemical shift of the secondary nucleus.

	What Makes Ricin Toxic? Ricin is one of the most toxic substances known to science with an LD50 between 3 and 30 µg/kg in humans. Potentially lethal when inhaled, ingested, or injected, death can occur within 36 to 72 hours upon exposure. Ricin works by preventing the body’s cells from producing essential proteins, which leads to cellular death. There is no known antidote for ricin poisoning.

	Researchers reveal undiscovered hot spots on surface of bacteria's critical enzyme Researchers reveal previously undiscovered hot spots on the surface of bacteria's critical enzyme, which could guide novel approaches to antibiotic design. Researchers have identified key sections of a bacterial enzyme that could be targeted with new drugs to inhibit the spread of some bacterial infections.

	Fat cells may be egging on melanoma cells to become more aggressive A new study has shown that fat cells could be implicated in the transformation of the melanoma cells in the skin into highly malignant cells that spread to the different organs of the body. A team from the Tel Aviv University, led by Prof. Carmit Levy and Dr. Tamar Golan of the Department of Human Genetics and Biochemistry at TAU's Sackler School of Medicine published their findings in the journal Science Signaling this week.