Psychiatric Disorders: New Genomic Insights - May 18, 2015

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Mental Health and Psychiatric Diseases

Psychiatric Disorders: New Genomic Insights - May 18, 2015

CDC and Related Info

• Burden of mental illness
• Suicide, Family History, and Genomics
• Mental Health Awareness & Genomics
• Coping with a traumatic event [PDF 142.11 KB] 
• Genes reported in relation to post traumatic stress disorder, including genomewide association studies via theHuGE Navigator
• Genes reported in relation to schizophrenia, including genomewide association studies via theHuGE Navigator

Mental Health Awareness Month: By the numbers
NIMH Director's Blog, May 2015

Optogenetics and the circuit dynamics of psychiatric disease
Deisseroth K, et al. JAMA 2015 May 14

Brain disorders? Precisely.
Insel TR et al. Science 2015 May 1. (6234) 499-500

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Psychiatric Genomics Consortium. Nature Neuroscience, January 19, 2015

The Psychiatric Genomics Consortium conducts mega-analyses of genome-wide genetic data for psychiatric disorders.

Genetic analysis of schizophrenia and bipolar disorder reveals polygenicity but also suggests new directions for molecular interrogation.
Neale BM, Sklar P. Curr Opin Neurobiol. 2015 Feb;30C:131-138.

Genetic determinants of depression: recent findings and future directions.
Dunn EC, et al. Harv Rev Psychiatry. 2015 Jan-Feb;23(1):1-18

Bioinformatic analyses and conceptual synthesis of evidence linking ZNF804A to risk for schizophrenia and bipolar disorder.
Hess JL, et al. Am J Med Genet B Neuropsychiatr Genet. 2015 Jan;168(1):14-35

Genetics of complex traits in psychiatry.
Gelernter J. Biol Psychiatry. 2015 Jan 1;77(1):36-42

Genomic insights into the overlap between psychiatric disorders: implications for research and clinical practice.
Doherty JL, Owen MJ. Genome Med. 2014 Apr 28;6(4):29.

Post Traumatic Stress Disorder: Public Health and Genomic Insights - May 18, 2015

What is Post-traumatic Stress Disorder (PTSD)?
Health Topics from the National Institute for Mental Health

Epigenetics of Posttraumatic Stress Disorder: current evidence, challenges, and future directions.
Zannas AS et al. Biol. Psychiatry 2015 Apr 7.

The Psychiatric Genomics Consortium Posttraumatic Stress disorder workgroup: posttraumatic stress disorder enters the age of large-scale genomic collaboration.
Logue MW et al. Neuropsychopharmacology 2015 Apr 23.

Biological correlates of complex posttraumatic stress disorder-state of research and future directions.
Marinova Z et al. Eur J Psychotraumatol 2015 25913

Systems biology approach to understanding post-traumatic stress disorder.
Thakur GS et al. Mol Biosyst 2015 Apr (4) 980-93

Progress towards understanding the genetics of posttraumatic stress disorder.
Voisey J et al. J Anxiety Disord 2014 Dec (8) 873-83

Searching for non-genetic molecular and imaging PTSD risk and resilience markers: Systematic review of literature and design of the German Armed Forces PTSD biomarker study.
Schmidt U et al. Psychoneuroendocrinology 2015 Jan 444-58

Mitochondrial genetic variants identified to be associated with posttraumatic stress disorder.
Flaquer A et al. Transl Psychiatry 2015 e524

Gene networks specific for innate immunity define post-traumatic stress disorder.
Breen M S et al. Mol. Psychiatry 2015 Mar 10.

The number of cysteine residues per mole in apolipoprotein E is associated with the severity of PTSD re-experiencing symptoms.
Peterson CK et al. J Neuropsychiatry Clin Neurosci 2015 (2) 157-61

Genomic predictors of combat stress vulnerability and resilience in U.S. Marines: A genome-wide association study across multiple ancestries implicates PRTFDC1 as a potential PTSD gene.
Nievergelt CM et al. Psychoneuroendocrinology 2015 Jan 459-71

Association of COMT and TPH-2 genes with DSM-5 based PTSD symptoms.
Goenjian AK et al. J Affect Disord 2014 Oct 22. 472-478

Variation in SLC1A1 is related to combat-related posttraumatic stress disorder.
Zhang J et al. J Anxiety Disord 2014 Dec (8) 902-7

Progress towards understanding the genetics of posttraumatic stress disorder.
Voisey J et al. J Anxiety Disord 2014 Dec (8) 873-83

Suicide: Recent Genomic Insights - March 2, 2015

Genome-wide association studies of suicidal behaviors: a review.
Sokolowski Marcus et al. Eur Neuropsychopharmacol2014 Oct (10) 1567-77

Two novel genomic rearrangements identified in suicide subjects using a-CGH array.
Lombardo Barbara et al. Clin. Chem. Lab. Med. 2015 Feb 13.

Investigating the role of early childhood abuse and HPA axis genes in suicide attempters with bipolar disorder.
Breen Marie E et al. Psychiatr. Genet. 2015 Feb 24.

Molecular convergence of neurodevelopmental disorders.
Chen Elizabeth S et al. Am. J. Hum. Genet. 2014 Nov 6. (5) 490-508

Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: a genome-wide association and polygenic scoring study.
Mullins Niamh et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2014 Jul (5) 428-37

Genome-wide methylomic analysis of monozygotic twins discordant for adolescent depression.
Dempster Emma L et al. Biol. Psychiatry 2014 Dec 15. (12) 977-83

A unique gene expression signature associated with serotonin 2C receptor RNA editing in the prefrontal cortex and altered in suicide.
Di Narzo Antonio Fabio et al. Hum. Mol. Genet. 2014 Sep 15. (18) 4801-13

Association study of GABRG2 polymorphisms with suicidal behaviour in schizophrenia patients with alcohol use disorder.
Zai Clement C et al. Neuropsychobiology 2014 (3) 154-8

Epigenetic studies of suicidal behavior.
Bani-Fatemi Ali et al. Neurocase 2015 (2) 134-43

Depression: Medical Research and Genomics - November 19, 2014

Mental health: The great depression. Depression causes more disability than any other disorder. A special issue explores how science can help. 
Nature, 12 November 2014 

The burden of depression: Mental health is gaining acceptance as a medical problem, but progress in finding treatments is being hampered by the stigma surrounding people's everyday experiences. 
Nature editorial 12 November 2014

Medical research: If depression were cancer. Research into depression has struggled, while studies of cancer have thrived — but the balance could be shifting. 
Heidi Ledford, Nature 12 November 2014

Mental health: Depression needs large human-genetics studies. 
Steven Hyman. Nature, 12 November 2014

Genomic insights into the overlap between psychiatric disorders: implications for research and clinical practice. 
Doherty JL, et al. Genome Med. 2014 Apr 28;6(4):29.

Biomarkers in major depressive disorder: the role of mass spectrometry.
Woods AG, et al. Adv Exp Med Biol. 2014;806:545-60.

Suicide Prevention: Family Health History & Genomics - September 18, 2014

CDC information: Suicide can be prevented. Each year, more than 39,000 Americans take their own lives and about 487,000 people receive medical care for self-inflicted injuries

New CDC blog post: Suicide, family health history, and genomics

CDC information: Risk factors for suicide include family history of suicide and family health history of child maltreatment

National Institute for Mental Health information: Suicide prevention

Did you know?>200 genes have been reported in relation to suicide risk, including 10 genomewide association studies? To find out more, visit the HuGE Navigator

Check out genetic conditions and tests associated with suicide, from the NIH Genetic Testing Registry

Could a genetic test predict the risk for suicide? Scientists are hunting for the genetic basis of suicide and developing suicide DNA tests, by Antonio Regalado, MIT Technology Review, Aug 13

Blood test that allegedly predicts suicide risk only looks promising in the media, not in science, by Cecile Janssens, Huffington Post, Aug 19

Team approach helps teen depression, by Dr. Francis Collins, NIH Director, Sep 9

Schizophrenia: Recent Genomic Insights - September 18, 2014

CDC information: Burden of mental illness

NIMH · Schizophrenia's genetic "skyline" rising

Exploring the complex genetics of schizophrenia, by Dr. Francis Collins, NIH Director's Blog, Jan 28

Did you Know? >1500 genes have been reported in relation to risk and outcomes of schizophrenia, including >200 genomewide association studies. To find out more, visit the HuGE Navigator

Check out genetic disorders and tests associated with schizophrenia, from the NIH Genetic Testing Registry

SZGene (SchizophreniaGene) Database: Field Synopsis of Genetic Association Studies in SZ

Uncovering the hidden risk architecture of the schizophrenias: confirmation in three independent genome-wide association studies
Javier Arnedo, et al. Am J Psychiatry 2014 Sep 15

Schizophrenia 'made up of eight specific genetic disorders', Medical News Today, Sep 15

Schizophrenia is eight different diseases, not one, by Liz Szabo, USA Today, Sep 15

Schizophrenia subtypes identified by combining genetic, clinical data, Genomeweb Daily, Sep 15

National Society of Genetic Counselors blog post : Is mental illness inherited? How family history and environment impact mental health

The causes of schizophrenia, from the National Alliance on Mental Illness 

Post Traumatic Stress Disorder: Recent Genomic Insights - August 21, 2014

CDC information on PTSD: Coping with a traumatic event  [PDF 142.11 KB] 

Risk factors for PTSD including having relatives with mental health problems, including PTSD or depression, from Mayo Clinic

Spread of genes implicated in post-traumatic stress disorder. Identification of possible genetic markers supports trauma treatment with steroid hormone. 
Helen Shen, Nature 11 August 2014

Did you know? 40 genes have been reported in relation to post traumatic stress disorder, including 1 genomewide association study. Find out more from the HuGE Navigator

Genome-wide association study implicates a novel RNA gene, the lincRNA AC068718.1, as a risk factor for post-traumatic stress disorder in women. 
Guffanti G, et al.  Psychoneuroendocrinology (2013)

In this Medical Edge Radio episode, Mayo Clinic Dr. James Rundell looks at our genetic make up in the context of post traumatic stress syndrome (2012).