Current Highlight from June 13, 2014
Novel Mechanism of Sertraline-Induced Liver Toxicity
Scientists from NCTR, the University of Maryland, and the University of Texas Southwestern Medical Center have shown that endoplasmic reticulum (ER) stress is a novel molecular mechanism of hepatic cytotoxicity induced by the antidepressant, sertraline, in an in vitro system. ER stress was detected in HepG2 (human liver carcinoma) cells treated with sertraline (at doses approximating human plasma levels) through analysis of gene and protein expression. Additionally, two in vitro reporter assays were developed to efficiently monitor ER stress-mediated liver toxicity. Sertraline is a widely prescribed antidepressant for which idiosyncratic liver injury has been reported. A manuscript detailing this study has been published in Toxicology
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.For additional information, please contact Lei Guo, Ph.D., Division of Biochemical Toxicology, FDA/NCTR.
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