Ahead of Print -Epidemiology, Clinical Manifestations, and Outcomes of Streptococcus suis Infection in Humans - Volume 20, Number 7—July 2014 - Emerging Infectious Disease journal - CDC
Figure 2. Global cumulative prevalence of Streptococcus suis infection through 2012.
Volume 20, Number 7—July 2014
Epidemiology, Clinical Manifestations, and Outcomes of Streptococcus suis Infection in Humans
Streptococcus suis is a neglected zoonotic pathogen that has caused large outbreaks of sepsis in China (1,2) and has been identified as the most common and the third leading cause of bacterial meningitis in adults in Vietnam and Hong Kong, respectively (3–5). S. suis infection is acquired from pigs, either during slaughtering or by handling and eating undercooked pork products. It is potentially preventable (3,6). Epidemiology of the infection differs between Western and Asian regions (7), and the role of high-risk eating habits (i.e., ingesting raw or undercooked pig parts, including pig blood, organs, and meat) in some Asian communities recently has been recognized (6,8,9). Rates of S. suis infection are low in the general populations of Europe and North America, and cases are concentrated among occupationally exposed groups, including abattoir workers, butchers, and pig breeders (10,11).
In a 2009 review, ≈700 S. suis infections were reported worldwide by 2009, mostly from China and Vietnam (12). Clinical characteristics of this infection have been reviewed (12,13) and include meningitis, sepsis, endocarditis, arthritis, hearing loss, and skin lesions. Treatment of S. suis infection requires ≈2 weeks of intravenous antimicrobial drugs (12). The death rate varies, and deafness is a common sequela in survivors.
Although substantial new data on the incidence, clinical and microbiological characteristics, and risk factors for S. suis infection have accumulated during recent years, the prevalence of this infection has not measurably decreased. We conducted a systematic review and meta-analysis to update the evidence and summarize the estimates of epidemiologic and clinical parameters to support practitioners’ and policy makers’ efforts to prevent and control this infection.
Suggested citation for this article:Huong VTL, Ha N, Huy NT, Horby P, Nghia HDT, Thiem VD, et al. Epidemiology, clinical manifestations, and outcomes of Streptococcus suis infection in humans. Emerg Infect Dis [Internet]. 2014 Jul [date cited]. http://dx.doi.org/10.3201/eid2007.131594
1These authors contributed equally to this article.