The genomic contribution to diabetes, by Katharine Hartley, PHG Foundation Briefing, January 2014
The genomic
contribution to
diabetes
Diabetes mellitus is a major public health concern estimated
to affect over 7% of the population in England 1. Risk
factors related to lifestyle - e.g. obesity and lack of exercise
- are well documented and are the focus for public health
interventions.
However, results from twin studies have established a genetic basis for
susceptibility to diabetes, although the genetic markers remained elusive until
recently. With the new ability to rapidly sequence DNA and conduct genome
wide association studies (GWAS) – the genetic contributors to the development
and progression of diabetes are now being revealed. Below we assess the
consequences for preventing, diagnosing and managing diabetes based on the
latest knowledge of the genomic contribution to the disease.
No hay comentarios:
Publicar un comentario