Clotting factor gene polymorphisms and colorectal ... [J Clin Oncol. 2011] - PubMed result

J Clin Oncol. 2011 May 1;29(13):1722-7. Epub 2011 Mar 21.
Clotting factor gene polymorphisms and colorectal cancer risk.
Vossen CY, Hoffmeister M, Chang-Claude JC, Rosendaal FR, Brenner H.
SourceDepartment of Medical Genetics, University Medical Center Utrecht, PO Box 85060, 3508 AB Utrecht, the Netherlands; c.y.vossen@umcutrecht.nl.


Abstract
PURPOSE Increased coagulation has been associated with cancer onset and progression. Mainly small studies have addressed the association between clotting factor gene polymorphisms and the onset of colorectal cancer. We examined the association between six well-known clotting factor gene polymorphisms and colorectal cancer risk in a large case-control study. PATIENTS AND METHODS Factor V Leiden (rs6025), prothrombin G20210A (rs1799963), PAI-1 4G/5G (rs1799889), MTHFR 677C>T (rs1801133), fibrinogen gamma 10034C>T (rs2066865), and factor XIII Val34Leu (rs5985) were genotyped in 1,801 patients with colorectal cancer and 1,853 healthy controls from a large German population-based study. The risk of colorectal cancer associated with gene variants was determined by calculating odds ratios (ORs) and their 95% CIs using logistic regression. Results Homozygous carriers of the prothrombotic factor V Leiden polymorphism showed a 5.8-fold increased risk (95% CI, 1.69 to 19.72) for colorectal cancer compared with noncarriers. A 30% reduced risk was found for heterozygous carriers of factor V Leiden (OR = 0.68; 95% CI, 0.52 to 0.90) and prothrombin G20210A (OR = 0.69; 95% CI, 0.49 to 0.96), implying an advantage for slightly increased thrombin generation. Carriers of the antithrombotic factor XIII Val34Leu polymorphism showed a 15% reduced risk of developing colorectal cancer (OR = 0.85; 95% CI, 0.74 to 0.97) compared with noncarriers. Our results did not support an effect of PAI-1 4G/5G, MTHFR 677C>T, and fibrinogen gamma 10034C>T on colorectal cancer risk. CONCLUSION Our results support a role of clotting factor polymorphisms and thereby the coagulation system in the risk of colorectal cancer.

PMID:21422408[PubMed - in process]
Clotting factor gene polymorphisms and colorectal ... [J Clin Oncol. 2011] - PubMed result