Epigenomics
Epimutations and cancer predisposition: importance and mechanisms
Hesson LB, et al.
Curr Opin Genet Dev 2010 Mar
Curr Opin Genet Dev. 2010 Mar 31. [Epub ahead of print]
Epimutations and cancer predisposition: importance and mechanisms.
Hesson LB, Hitchins MP, Ward RL.
Lowy Cancer Research Centre and Prince of Wales Clinical School, University of New South Wales, Kensington, New South Wales, Australia.
Abstract
Germline sequence mutations in tumour suppressor genes can cause cancer predisposition syndromes. More recently, epimutations have also been proposed to cause at least one such syndrome, hereditary non-polyposis colorectal cancer (HNPCC). 'Epigenetic predisposition', is defined as an inherited propensity to an altered epigenetic state in normal tissues that confers a predisposition to disease. Genetic sequence variations acting in cis or trans may contribute to epigenetic variations. Understanding the origin of epimutations will inform cancer risk assessment and will also aid the design and application of new therapies that target the epigenome. Copyright © 2010 Elsevier Ltd. All rights reserved.
PMID: 20359882 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20359882?dopt=Abstract
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