PLoS Currents: Evidence on Genomic Tests
Rapid and open sharing of brief summaries with researchers and the public.
Health-related applications of genomic research are increasingly available to practitioners and the public but information on their validity and utility is often fragmented. PLoS Currents: Evidence on Genomic Tests aims to provide updated summaries of available data and to highlight gaps in knowledge. All content is reviewed by a group of expert researchers.
PLoS Currents: Evidence on Genomic Tests - a collection by PLoS
1.
Women with early stage breast cancer frequently receive adjuvant chemotherapy to prevent recurrence; however, not all...
2.
Bladder cancer is the fourth most common cancer in males worldwide and also the most expensive cancer to treat. Approximat...
3.
Individuals with Lynch syndrome, sometimes referred to as hereditary non-polyposis colorectal cancer (HNPCC), have an...
4.
Lung cancer is the second most common cancer and the leading cause of cancer-related deaths in the United States. Moreover...
5.
Familial hypercholesterolemia (FH) is an autosomal dominant disorder characterized by abnormally high concentrations of...
6.
Azathioprine (AZA), 6-mercaptopurine (6-MP), and thioguanine (TG) are thiopurine drugs. These agents are indicated for the...
7.
Colorectal cancer is the third most common cancer and the second leading cause of cancer-related deaths in the United Stat...
8.
Type 2 diabetes (T2D) is a common disease caused by a complex interplay between many genetic and environmental factors....
9.
Hepatitis C virus (HCV) is a bloodborne infection that is one of the leading causes of liver disease. If left untreated, H...
10.
Tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of chronic myeloid leukemia (CML). Although randomized...
11.
Abacavir is a nucleoside reverse transcriptase inhibitor used for combination antiretroviral therapy for treating human...
12.
Worldwide, lung cancer accounts for approximately 1 million deaths each year, making it the most common cause of...
13.
Coronary artery disease (CAD) is a leading cause of death worldwide and in the United States it is responsible for more th...
14.
BRAF p.Val600Glu (V600E) Testing for Assessment of Treatment Options in Metastatic Colorectal Cancer
Colon and rectal cancer (CRC) are the third most common cancer in the United States and cause approximately 50,000 deaths ...
15.
It is estimated that approximately 22,000 Americans will be diagnosed with tumor of the brain or nervous system in 2010....
16.
The anti-platelet agent clopidogrel bisulfate (sold under the trade name Plavix in the United States) is a widely prescrib...
17.
Warfarin is an oral anticoagulant that is widely prescribed to prevent thromboembolic events in persons at increased risk....
18.
KRAS mutational analysis is a genetic test used in clinical practice for determining the status of the KRAS gene (wild typ...
19.
Tamoxifen, a selective estrogen receptor modulator, is the standard of care for premenopausal women with estrogen or...
20.
Overall five-year survival for patients with stage-II colon cancer averages 75% after surgery alone. However, some of thes...
21.
Differences in the expression of specific genes within breast tumors have been associated with risk of recurrence after...
22.
Evidence on Genomic Tests is an open access publication option for communicating high-quality, scientific information that...
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