sábado, 15 de octubre de 2011

Role of family history for Alzheimer biomarker a... [Arch Neurol. 2011] - PubMed - NCBI

Arch Neurol. 2011 Oct;68(10):1313-9.

Role of family history for Alzheimer biomarker abnormalities in the adult children study.

Source

Department of Biostatistics, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8067, St Louis, MO 63110. chengjie@wubios.wustl.edu .

Abstract

OBJECTIVE:

To assess whether family history (FH) of Alzheimer disease (AD) alone influences AD biomarker abnormalities.

DESIGN:

Adult Children Study.

SETTING:

Washington University's Charles F. and Joanne Knight Alzheimer's Disease Research Center.

PARTICIPANTS:

A total of 269 cognitively normal middle- to older-aged individuals with and without an FH for AD.

MAIN OUTCOME MEASURES:

Clinical and cognitive measures, magnetic resonance imaging-based brain volumes, diffusion tensor imaging-based white matter microstructure, cerebrospinal fluid biomarkers, and molecular imaging of cerebral fibrillar amyloid with positron emission tomography using the [(11)C] benzothiazole tracer, Pittsburgh compound B.

RESULTS:

A positive FH for AD was associated with an age-related decrease of cerebrospinal fluid Aβ42; the ε4 allele of apolipoprotein E (APOE4) did not alter this effect. Age-adjusted cerebrospinal fluid Aβ42 was decreased for individuals with APOE4 compared with the level for those without, and the decrease was larger for individuals with a positive FH compared with the decrease for those without. The variation of cerebrospinal fluid tau and Pittsburgh compound B mean cortical binding potential increased by age. For individuals younger than 55, an age-related increase in mean cortical binding potential was associated with APOE4 but not FH. For individuals older than 55, a positive FH and a positive APOE4 implied the fastest age-related increase in mean cortical binding potential. A positive FH was associated with decreased fractional anisotropy from diffusion tensor imaging in the genu and splenium of the corpus callosum.

CONCLUSION:

Independent of APOE4, FH is associated with age-related change of several cerebrospinal fluid, Pittsburgh compound B, and diffusion tensor imaging biomarkers in cognitively normal middle- to older-aged individuals, suggesting that non- APOE susceptibility genes for AD influence AD biomarkers.

PMID:
21987546
[PubMed - in process]
Role of family history for Alzheimer biomarker a... [Arch Neurol. 2011] - PubMed - NCBI

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