sábado, 22 de octubre de 2011

Human infection with novel G3P[25] rot... [Clin Microbiol Infect. 2011] - PubMed - NCBI

Clin Microbiol Infect. 2011 Oct;17(10):1570-1573. doi: 10.1111/j.1469-0691.2011.03531.x. Epub 2011 Aug 18.

Human infection with novel G3P[25] rotavirus strain in Taiwan.

Wu FT, Bányai K, Huang JC, Wu HS, Chang FY, Hsiung CA, Huang YC, Lin JS, Hwang KP, Jiang B, Gentsch JR.

Source

Department of Health, Centre for Research and Diagnostics, Centres for Disease Control, Taiwan Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University, Taipei, Taiwan Veterinary Medical Research Institute, Budapest, Hungary School of Medical Laboratory Science and Biotechnology, Taipei Medical University, Taipei, Taiwan Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan Division of Paediatric Infectious Disease, Chang Gung Children's Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan Division of Paediatric Infectious Disease and Department of Laboratory Medicine, Changhua Christian Hospital, Changhua, Taiwan Division of Paediatric Infectious Disease, Department of Paediatrics, Chang Gung Memorial Hospital, Kaohsiung Medical Centre, Chang Gung University College of Medicine, Kaohsiung, Taiwan School of Medicine, Children's Hospital, China Medical University and Hospitals, Taichung, Taiwan Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Abstract

Clin Microbiol Infect 2011; 17: 1570-1573 ABSTRACT: Genotype P[25] rotaviruses are rare and to date have been reported to occur only in a few countries of mainland Asia. Here we report the molecular characterization of a novel human rotavirus genotype combination, G3P[25], detected in a 17-month-old child hospitalized due to severe gastroenteritis during 2009 in central Taiwan. Sequencing and phylogenetic analysis of the VP4 gene demonstrated a distinct origin from other strains bearing the P[25] VP4 gene, whereas the VP7, VP6 and NSP4 gene phylogenies identified common origins with cognate genes of other, presumed human-porcine reassortment Taiwanese strains. These results suggest that interactions between human and animal strains appear to contribute to the generation of genetic and antigenic diversity of rotavirus strains, with potential public health importance in Taiwan.
© 2011 The Authors. Clinical Microbiology and Infection © 2011 European Society of Clinical Microbiology and Infectious Diseases.