CIENCIASMEDICASNEWS: Medical News | Medical Articles: QC of Ligand Binding Assay Reagents (LBAs)

miércoles, 26 de junio de 2019

Medical News | Medical Articles: QC of Ligand Binding Assay Reagents (LBAs)

	June 26, 2019
	Biochemistry
	The latest biochemistry news from AZoNetwork

QC of Ligand Binding Assay Reagents (LBAs)

To ensure that LBAs utilizing conjugated drug reagents perform consistently over time and provide high quality data, each lot should be characterized for aggregation by SEC-MALS.

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Tips For Better Biochemistry Research with Easier Experiment Records

Lost results and issues with experiment records are key frustrations for biochemistry researchers, along with poor media management and difficulty keeping track of important documents in a paper trail. See the latest tips for better research through easier record keeping.

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Analytical Techniques used in Human Biomonitoring

There has been a surge in the presence of pollutants and contaminants in the environment. Thus, efforts are being made to develop techniques that can measure the presence of these molecules within the body, in a process known as human biomonitoring.

	What is Microdialysis? Microdialysis is a valuable tool in neuroscience that can be used to investigate and learn about complex brain functions through the collection of small-molecular-weight substances from the extracellular fluid or interstitial space.

	LC-MS/MS test for progesterone outperforms traditional immunoassays Researchers have devised a cheap, non-invasive and specific means to monitor progesterone production in women. The new technique uses saliva and liquid chromatography-tandem mass spectrometry (LC-MS/MS). The research was published in the Annals of Clinical Biochemistry.

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	Acetolactate Synthase Structure, Function, and Drug Development Acetolactate synthase can be found in plants, fungi, archaea, and bacteria, but not animals. This enzyme is involved in condensing two pyruvate molecules to form acetolactate, or pyruvate and 2-ketobutyrate. This leads to the formation of acetohydroxybutyrate (AHB). In the case of eubacteria, like E.coli or Salmonella typhimurium, three types of acetolactate synthase (AHAS) enzymes are present: AHAS I, AHAS II, AHAS III. However, in E.coli, AHAS II is inactive, while in Salmonella, AHAS III is inactive.

	What is the Hepatic Microsomal Enzyme System? Drugs are metabolized in the liver using several enzyme-catalyzed processes. These enzymes are collectively referred to as the hepatic microsomal enzyme system, and they are usually present in the endoplasmic reticulum of hepatocytes.

	Scientists delay aging using protein found in young mice Scientists have shown that a protein which is abundant in the blood of young mice can delay the aging process and improve the activity levels of older mice. The study was carried out by researchers at the Washington University School of Medicine in St. Louis and the results were published in the journal Cell Metabolism on June 13, 2019.