CIENCIASMEDICASNEWS: Medical News | Medical Articles: A Look at HDAC Antibodies

miércoles, 26 de junio de 2019

Medical News | Medical Articles: A Look at HDAC Antibodies

	June 26, 2019
	Antibodies
	The latest antibodies news from News Medical

A look at HDAC antibodies

Many vital cell programs such as regulation of transcription, progression of the cell cycle and other developmental occurrences depend upon the two-way acetylation-deacetylation of highly conserved lysine residues inside the N-terminal tail domains of the histones at the DNA core. The acetylation of histones proceeds dynamically, in accordance with the level of activity of two competing sets of enzymes, the histone acetyltransferases (HATs) and histone deacetylases (HDACs).

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			Researchers develop DNA nanorobots that target breast cancer cells Researchers have developed a DNA nanorobot that recognizes HER2 on breast cancer cells, targeting them for destruction. The nanorobot could one day replace monoclonal antibodies, they say.

			New DNA Microscopy Technique Offers Novel Insight into Genomic Information in Cells Scientists are now able to see inside cells to a genomic level with a newly invented imaging technique called DNA microscopy. Using DNA “bar codes”, DNA microscopy allows scientists to locate a molecule’s position in a sample without using any kind of optics, meaning genomic information can be collected in large amounts.

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	ELISA test performed in 3D-printed pipette tips simplifies process, reduces cost Scientists have taken a common, yet laborious lab test and redesigned it to be performed in small 3D printed pipette tips used to measure and transfer fluids in the laboratory.

	Novel microfluidic device captures and isolates circulating tumor cell clusters Scientists have developed a microfluidic device that can facilitate the capture of circulating tumor cells via antibodies. They also developed a unique alginate hydrogel channel coating that can be readily decorated with antibodies or other biomolecules

	A novel approach to intraplaque mast cell characterization in atherosclerosis Researchers from Leiden University in the Netherlands have developed a new technique for characterizing intraplaque mast cells; the primary immune mediators of atherosclerotic plaque development.

	Newly discovered antibody broadly inhibits multiple strains of pandemic norovirus Researchers have described for the first time the structure of the binding interaction between the virus and a human antibody that may work against many strains of norovirus.